Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings.
Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings.
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DOI：
10.1016/j.pscychresns.2014.09.002
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发表时间：
2014-12-30
影响因子：
11.3
通讯作者：
Wolkowitz OM
中科院分区：
文献类型：
--
作者：
Lindqvist D;Mueller S;Mellon SH;Su Y;Epel ES;Reus VI;Rosser R;Mahan L;Mackin RS;Yang TT;Wolkowitz OM
几种精神疾病，包括重度抑郁症（MDD），与氧化应激的血液标志物增加有关。这与氧化敏感海马（HC）的相关性尚不清楚。我们研究了外周氧化应激标志物和HC体积之间的关系，在未用药的MDD患者（n=16）和健康对照组（n=19）。为了节省能量，我们的主要分析在合并的受试者组中进行，次要分析分别检查各组。评估氧化应激标志物（氧化型谷胱甘肽）和抗氧化剂（还原型谷胱甘肽、谷胱甘肽过氧化物酶、维生素C），并计算“总净抗氧化剂评分”。4-T MRI估计总HC体积和HC子区（CA 1、CA 1-CA 2过渡区、下托和CA 3/齿状回[CA 3 & DG]）体积。在各组中，抗氧化评分与总HC体积和CA 3和DG子区域体积（标准化为总颅内体积）显著正相关，并对年龄和性别进行了调整。在每个单独的组中观察到类似的关系，但失去了统计学意义，可能是由于II型错误，除了MDD组中抗氧化剂评分与CA 3和DG体积之间的显著相关性。这些初步数据与氧化应激相一致，氧化应激与较小的总HC和CA3&DG子域体积相关。
Several psychiatric disorders, including major depressive disorder (MDD), are associated with increased blood markers of oxidative stress. The relevance of this to the oxidation-sensitive hippocampus (HC) is unknown. We investigated the relationship between peripheral oxidative stress markers and HC volume in unmedicated individuals with MDD (n=16) and healthy controls (n=19). To conserve power, our primary analysis was carried out in the combined group of subjects, and secondary analyses examined each group separately. Oxidative stress markers (oxidized glutathione) and antioxidants (reduced glutathione, glutathione peroxidase, Vitamin C) were assessed, and a “total net antioxidant score” was calculated. 4-T MRI estimated total HC volume and HC subfield (CA1, CA1-CA2 transition zone, subiculum and CA3/dentate gyrus [CA3&DG]) volumes. Across groups, the antioxidant score was significantly and positively correlated with total HC volume and CA3&DG subfield volume (normalized to total intracranial volume), adjusting for age and sex. Similar relationships were observed in each individual group but missed statistical significance, likely due to type II errors, with the exception of a significant correlation between the antioxidant score and CA3&DG volume in the MDD group. These preliminary data are consistent with oxidative stress being associated with smaller total HC and CA3&DG subfield volumes.
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影响因子：
4.8
作者：
Mueller, Susanne G.;Schuff, Norbert;Yaffe, Kristine;Madison, Catherine;Miller, Bruce;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
影响因子：
10.5
作者：
Hickie, I;Naismith, S;Parker, G
通讯作者：
Parker, G
影响因子：
4.2
作者：
Qiu, Shenfeng;Li, Liying;May, James M.
通讯作者：
May, James M.
影响因子：
4.7
作者：
Bearden CE;Thompson PM;Avedissian C;Klunder AD;Nicoletti M;Dierschke N;Brambilla P;Soares JC
通讯作者：
Soares JC
影响因子：
4.3
作者：
Che, Yi;Wang, Jun-Feng;Young, L. Trevor
通讯作者：
Young, L. Trevor