Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease.
Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease.
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DOI：
10.1002/hbm.20934
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发表时间：
2010-09
影响因子：
4.8
通讯作者：
Weiner, Michael W.
中科院分区：
文献类型：
--
作者：
Mueller, Susanne G.;Schuff, Norbert;Yaffe, Kristine;Madison, Catherine;Miller, Bruce;Weiner, Michael W.
组织病理学研究和动物模型表明，衰老、阿尔茨海默病(AD)和其他疾病可能会对海马区产生不同的影响。4特斯拉的高分辨率图像描绘了海马体内部结构的细节，允许在体内测量不同亚区的体积。本研究的目的如下：(1)确定正常衰老、AD和遗忘性轻度认知损害(MCI)患者海马区的体积丢失模式。(2)确定测量海马区是否优于海马区总体积以区分不同组间的差异。91名受试者(53名对照组，平均年龄：69.3±7.3岁)、20名MCI患者(平均年龄：73.6±7.1岁)和18名AD患者(平均年龄：69.1±9.5岁)进行了针对海马区的高分辨率T2加权成像。在海马体前1/3处手工标记内嗅皮层(ERC)、下丘脑、CA1、CA1-CA2过渡区(CA1-2)、CA3&齿状回(CA3&DG)。自由游泳法获取大鼠海马区体积，手工编辑。AD组ERC、下丘脑、CA1、CA1-2的体积和海马区总体积均小于对照组。MCI的CA1-2体积较小。判别分析和功率分析表明，CA1-2在区分对照组和MCI方面优于海马区总体积。AD和MCI的亚场萎缩模式与组织病理学所描述的神经细胞丢失/突触密度降低的模式一致。这些初步发现表明，海马子区体积测量可能是诊断早期AD和检测其他疾病影响的一种比测量总海马区更好的方法。
Histopathological studies and animal models suggest that hippocampal subfields may be differently affected by aging, Alzheimer’s disease (AD), and other diseases. High-resolution images at 4 Tesla depict details of the internal structure of the hippocampus allowing for in vivo volumetry of different subfields. The aims of this study were as follows: (1) to determine patterns of volume loss in hippocampal subfields in normal aging, AD, and amnestic mild cognitive impairment (MCI). (2) To determine if measurements of hippocampal subfields provide advantages over total hippocampal volume for differentiation between groups. Ninety-one subjects (53 controls (mean age: 69.3 ± 7.3), 20 MCI (mean age: 73.6 ± 7.1), and 18 AD (mean age: 69.1 ± 9.5) were studied with a high-resolution T2 weighted imaging sequence aimed at the hippocampus. Entorhinal cortex (ERC), subiculum, CA1, CA1–CA2 transition zone (CA1-2), CA3 & dentate gyrus (CA3&DG) were manually marked in the anterior third of the hippocampal body. Hippocampal volume was obtained from the Freesurfer and manually edited. Compared to controls, AD had smaller volumes of ERC, subiculum, CA1, CA1-2, and total hippocampal volumes. MCI had smaller CA1-2 volumes. Discriminant analysis and power analysis showed that CA1-2 was superior to total hippocampal volume for distinction between controls and MCI. The patterns of subfield atrophy in AD and MCI were consistent with patterns of neuronal cell loss/reduced synaptic density described by histopathology. These preliminary findings suggest that hippocampal subfield volumetry might be a better measure for diagnosis of early AD and for detection of other disease effects than measurement of total hippocampus.
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DOI：
10.1073/pnas.0400285101
发表时间：
2004-05-04
影响因子：
11.1
作者：
Small, SA;Chawla, MK;Barnes, CA
通讯作者：
Barnes, CA
影响因子：
19.7
作者：
Colliot, Olivier;Chetelat, Gael;Lehericy, Stephane
通讯作者：
Lehericy, Stephane
影响因子：
9.9
作者：
Xu, Y;Jack, CR;Petersen, RC
通讯作者：
Petersen, RC
影响因子：
2.6
作者：
De Vita, E;Thomas, DL;Ordidge, RJ
通讯作者：
Ordidge, RJ
影响因子：
4.2
作者：
Pennanen, C;Kivipelto, M;Soininen, H
通讯作者：
Soininen, H