Fatty fish, marine omega-3 fatty acids and incidence of heart failure.

Fatty fish, marine omega-3 fatty acids and incidence of heart failure.
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DOI:
10.1038/ejcn.2010.50
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发表时间:
2010-06
影响因子:
4.7
通讯作者:
--
中科院分区:
医学3区
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海洋ω - 3脂肪酸对心血管危险因素具有有益影响。食用富含脂肪的鱼类和海洋ω - 3脂肪酸与较低的心血管疾病发病率相关。 我们在中老年女性人群中研究了富含脂肪的鱼类和海洋ω - 3脂肪酸与心力衰竭(HF)之间的关联。 瑞典乳腺X线摄影队列中年龄在48 - 83岁的参与者完成了96项食物频率问卷调查。在基线时无心力衰竭、心肌梗死或糖尿病病史的女性(n = 36234)从1998年1月1日至2006年12月31日通过瑞典住院患者和死因登记处进行随访,以了解心力衰竭住院或死亡情况;651名女性发生了心力衰竭事件。采用考虑年龄和其他混杂因素的考克斯比例风险模型来计算发病率比值(RR)和95%置信区间(CI)。 与不吃富含脂肪的鱼类的女性相比,每周食用<1份的RR为0.86(95% CI:0.67,1.10),每周食用1份的RR为0.80(95% CI:0.63,1.01),每周食用2份的RR为0.70(95% CI:0.53,0.94),每周食用≥3份的RR为0.91(95% CI:0.59,1.40)(趋势P = 0.049)。海洋ω - 3脂肪酸五分位数的RR分别为1(参考值)、0.85(95% CI:0.67,1.07)、0.79(95% CI:0.61,1.02)、0.83(95% CI:0.65,1.06)和0.75(95% CI:0.58,0.96)(趋势P = 0.04)。 在该人群中,适量食用富含脂肪的鱼类(每周1 - 2份)和海洋ω - 3脂肪酸与首次心力衰竭住院或死亡的发生率较低有关。
Marine omega-3 fatty acids have beneficial effects on cardiovascular risk factors. Consumption of fatty fish and marine omega-3 has been associated with lower rates of cardiovascular diseases. We examined the association of fatty fish and marine omega-3 with heart failure (HF) in a population of middle-age and older women. Participants in the Swedish Mammography Cohort aged 48–83 years completed 96-item food-frequency questionnaires. Women without history of HF, myocardial infarction, or diabetes at baseline (n= 36 234) were followed from January 1, 1998 until December 31, 2006 for HF hospitalization or mortality through Swedish inpatient and cause-of-death registers; 651 women experienced HF events. Cox proportional hazards models accounting for age and other confounders were used to calculate incidence rate ratios (RR) and 95% confidence intervals (CI). Compared to women who did not eat fatty fish, RR were 0.86 (95% CI: 0.67, 1.10) for <1 serving/week, 0.80 (95% CI: 0.63, 1.01) for 1 serving/week, 0.70 (95% CI: 0.53, 0.94) for 2 servings/week, and 0.91 (95% CI: 0.59, 1.40) for ≥3 servings/week (Ptrend = 0.049). RR across quintiles of marine omega-3 fatty acids were 1 (reference), 0.85 (95% CI: 0.67, 1.07), 0.79 (95% CI: 0.61, 1.02), 0.83 (95% CI 0.65, 1.06), and 0.75 (95% CI: 0.58, 0.96) (Ptrend = 0.04). Moderate consumption of fatty fish (one to two servings per week) and marine omega-3 fatty acids were associated with a lower rate of first HF hospitalization or death in this population.
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