Adolescent neuroimmune function and its interaction with alcohol.
Adolescent neuroimmune function and its interaction with alcohol.
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DOI：
10.1016/bs.irn.2021.08.006
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发表时间：
2022
影响因子：
--
通讯作者：
Deak, T.
中科院分区：
文献类型：
--
作者：
Doremus-Fitzwater, T. L.;Deak, T.
青春期是一个进化保守的发展时期，与行为变化有关，包括增加冒险和饮酒。酒精的实验通常始于青春期，然后过渡到暴饮暴食的消费模式。青春期的酒精暴露会改变大脑结构和功能的正常变化。了解乙醇影响神经发育过程的机制对于预防和改善青少年酒精滥用的有害后果非常重要。本文综述了神经免疫系统作为一个关键的贡献者乙醇引起的青少年大脑和行为的变化。简要回顾神经免疫系统的发展，急性和慢性乙醇对青少年神经免疫功能的影响。压力/免疫挑战和乙醇对青少年神经免疫的比较进行了审查，交叉致敏是相关的青春期。乙醇改变神经免疫功能的机制进行了讨论，因为它们可能预示着神经病理学后果的发展，从而增加对随后挑战的脆弱性，并增强成瘾行为。
Adolescence is an evolutionarily conserved developmental period associated with behavioral change, including increased risk-taking and alcohol use. Experimentation with alcohol typically begins in adolescence and transitions to binge-like patterns of consumption. Alcohol exposure during adolescence can alter normative changes in brain structure and function. Understanding mechanisms by which ethanol impacts neurodevelopmental processes is important for preventing and ameliorating the deleterious consequences of adolescent alcohol abuse. This review focuses on the neuroimmune system as a key contributor to ethanol-induced changes in adolescent brain and behavior. After brief review of neuroimmune system development, acute and chronic effects of ethanol on adolescent neuroimmune functioning are addressed. Comparisons between stress/immunological challenges and ethanol on adolescent neuroimmunity are reviewed, as cross-sensitization is relevant during adolescence. The mechanisms by which ethanol alters neuroimmune functioning are then discussed, as they may portend development of neuropathological consequences and thus increase vulnerability to subsequent challenges and potentiate addictive behaviors.
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