Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.
Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.
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DOI：
10.1111/j.1748-1716.2010.02237.x
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Barton M
中科院分区：
文献类型：
--
作者：
Meyer MR;Clegg DJ;Prossnitz ER;Barton M
肥胖通过胰岛素抵抗、糖尿病、动脉高血压和血脂异常增加冠状动脉疾病的风险。肥胖症的流行率在世界范围内有所增加，在中年妇女和男子中尤其高。绝经后，由于内源性卵巢激素分泌的丧失，女性患内脏肥胖的风险增加。雌激素的作用通常由两种核雌激素受体（ER）α和β介导。此外，最近的研究表明，细胞内跨膜G蛋白偶联的雌激素受体，GPER，最初命名为GPR30，也介导了一些归因于雌激素的作用。雌激素及其受体不仅在女性中是体重和胰岛素敏感性的重要调节剂，而且在男性中也是如此，如啮齿动物和人类的ER突变所证明的。本文综述了性激素和雌激素受体在肥胖、胰岛素敏感性和糖尿病中的作用以及女性和男性的相关临床问题。
Obesity increases the risk of coronary artery disease through insulin resistance, diabetes, arterial hypertension, and dyslipidemia. The prevalence of obesity has increased worldwide and is particularly high among middle-aged women and men. After menopause, women are at an increased risk to develop visceral obesity due to the loss of endogenous ovarian hormone production. Effects of estrogens are classically mediated by the two nuclear estrogen receptors (ERs) α and β. In addition, more recent research has shown that the intracellular transmembrane G protein-coupled estrogen receptor, GPER, originally designated as GPR30, also mediates some of the actions attributed to estrogens. Estrogen and its receptors are important regulators of body weight and insulin sensitivity not only in women, but also in men as demonstrated by ER mutations in rodents and humans. This article reviews the role of sex hormones and estrogen receptors in the context of obesity, insulin sensitivity and diabetes as well as the related clinical issues in females and males.
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影响因子：
3.6
作者：
Baptista, T;DeBaptista, EA;Weiss, SR
通讯作者：
Weiss, SR
雌激素受体ERα调节胰腺胰岛素含量。
影响因子：
3.7
作者：
Alonso-Magdalena, Paloma;Ropero, Ana B.;Carrera, M. Pilar;Cederroth, Christopher R.;Baquie, Mathurin;Gauthier, Benoit R.;Nef, Serge;Stefani, Enrico;Nadal, Angel
通讯作者：
Nadal, Angel
影响因子：
8.2
作者：
BAILEY, CJ;AHMEDSOROUR, H
通讯作者：
AHMEDSOROUR, H
影响因子：
3.2
作者：
Bramlage, P;Pittrow, D;Sharma, AM
通讯作者：
Sharma, AM
影响因子：
8.3
作者：
Barton, M;Carmona, R;Shaw, S
通讯作者：
Shaw, S