Long-term unemployment is associated with short telomeres in 31-year-old men: an observational study in the northern Finland birth cohort 1966.
Long-term unemployment is associated with short telomeres in 31-year-old men: an observational study in the northern Finland birth cohort 1966.
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DOI：
10.1371/journal.pone.0080094
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Järvelin MR
中科院分区：
文献类型：
--
作者：
Ala-Mursula L;Buxton JL;Ek E;Koiranen M;Taanila A;Blakemore AI;Järvelin MR
由早期生活经历和家庭压力引起的生活压力与较短的白细胞端粒长度(LTL)有关，但关于就业相关压力的证据很少。我们探索了成年早期的失业是否与LTL缩短有关，LTL是过早衰老的潜在生物标记物。我们使用了来自1966年芬兰北部出生队列的5620名男性和女性的数据。将1995-97年的个人登记失业天数与1997-98年随访时通过调查和临床检查获得的生物、行为和社会经济健康预测因素和现有医疗状况的数据进行比较。采用多重实时荧光定量聚合酶链式反应(MQRT)检测平均LTL。根据失业天数为0、260、500和500天以上，分别代表0、1、2和2个日历年，计算属于标准化相对平均LTL的性别分层最短十进制的优势比及其95%可信区间(CI)。在男性中，与连续受雇相比，三年内失业超过500天与随访时的LTL较短有关。在完全调整的模型中，相应的优势比为2.61(95%CI为1.16比5.85)。在这项研究中，女性中没有发现这种关联。成年早期的长期失业与男性较短的LTL有关。
Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging. We used data from 5620 men and women belonging to the Northern Finland Birth Cohort 1966. Individually registered unemployment days in 1995–97 were compared with data on biological, behavioral and socioeconomic health predictors and existing medical conditions obtained by surveys and clinical examinations at follow-up in 1997–98. Mean LTL at follow-up was measured by multiplex quantitative real-time PCR. We calculated odds ratios and their 95% confidence intervals (CI) of belonging to the sex-stratified shortest decile of standardized relative mean LTL according to the categories of: 0, <260, <500 and over 500 unemployment days, representing 0, <1, <2 and over 2 calendar years. Among men, unemployment exceeding 500 days during three years was associated with having shorter LTL at follow-up, compared to being continuously employed. The corresponding odds ratio was 2.61 (95% CI 1.16 to 5.85) in the fully adjusted model. Such an association was not found among women in this study. Long-term unemployment in early adulthood is associated with shorter LTL among men.
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在健康、衰老和身体成分研究中，累积炎症负荷与白细胞端粒长度短有关。
影响因子：
3.7
作者：
O'Donovan A;Pantell MS;Puterman E;Dhabhar FS;Blackburn EH;Yaffe K;Cawthon RM;Opresko PL;Hsueh WC;Satterfield S;Newman AB;Ayonayon HN;Rubin SM;Harris TB;Epel ES;Health Aging and Body Composition Study
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Health Aging and Body Composition Study
影响因子：
3.7
作者：
Farzaneh-Far R;Lin J;Epel E;Lapham K;Blackburn E;Whooley MA
通讯作者：
Whooley MA
影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
DOI：
10.1097/jom.0b013e3181d5e371
发表时间：
2010-05-01
影响因子：
3.2
作者：
Davila, Evelyn P.;Christ, Sharon L.;Fleming, Lora E.
通讯作者：
Fleming, Lora E.
影响因子：
7.7
作者：
Ehrlenbach, Silvia;Willeit, Peter;Brandstaetter, Anita
通讯作者：
Brandstaetter, Anita