Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study.
Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study.
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DOI：
10.3390/ijerph17207377
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发表时间：
2020-10-10
影响因子：
--
通讯作者：
Roh HT
中科院分区：
文献类型：
--
作者：
Woo J;Min JH;Lee YH;Roh HT
本研究的目的是探讨高压氧治疗 (HBOT) 对常压、常氧 (NN) 和低压、低氧 (HH) 环境中急性运动后炎症、氧化/抗氧化平衡和肌肉损伤的影响。选择 18 名健康男性，随机分为三组：NN 条件下运动（NN 组，n = 6）、NN 条件下运动后 HBOT 治疗（HNN 组，n = 6）和 HH 条件下运动后 HBOT 治疗（HHH 组，n = 6）。所有受试者在每种条件下以 75-80% 最大心率 (HRmax) 运动强度在跑步机上跑步 60 分钟。 HBOT 治疗包括在 2.5 个绝对大气压 (ATA) 下呼吸 100% 氧气 60 分钟。运动前 (BE)、运动后 (AE) 和 HBOT 后 (AH) 采集血样，以检查炎症（纤维蛋白原、白细胞介素 6 [IL-6] 和肿瘤坏死因子 α (TNF-α)）、氧化/抗氧化平衡（活性氧代谢物 (d-ROM) 衍生物和生物抗氧化潜力 (BAP)）和肌肉损伤（肌酸激酶 (CK) 和乳酸脱氢酶） （LDH））。与 BE 相比，所有组中 AE 的血浆纤维蛋白原、血清 IL-6、CK 和 LDH 水平均显着升高 (p < 0.05)。与 AE 组相比，所有组中血浆纤维蛋白原水平均显着降低（p < 0.05），并且与 BE 组相比，HNN 组的 AH 显着降低（p < 0.05）。与 AE 相比，HNN 和 HHH 组的血清 IL-6 水平显着降低 (p < 0.05)。与 HHH 组中的 AE 相比，AH 组的血清 CK 水平显着降低（p < 0.05）。与AE相比，HNN和HHH组的血清LDH水平显着降低（p < 0.05），并且与BE相比，NN和HNN组的AH血清LDH水平显着升高（p < 0.05）。这些结果表明，在 NN 和 HH 环境中进行急性运动可能会引起暂时性炎症反应和肌肉损伤，而 HBOT 治疗可能可以有效减轻运动引起的炎症反应和肌肉损伤。
The purpose of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on inflammation, the oxidative/antioxidant balance, and muscle damage after acute exercise in normobaric, normoxic (NN) and hypobaric, hypoxic (HH) environments. Eighteen healthy males were selected and randomly assigned to three groups: exercise in NN conditions (NN group, n = 6), HBOT treatment after exercise in NN conditions (HNN group, n = 6), and HBOT treatment after exercise in HH conditions (HHH group, n = 6). All subjects performed treadmill running for 60 min at 75–80% maximum heart rate (HRmax) exercise intensity under each condition. The HBOT treatments consisted of breathing 100% oxygen at 2.5 atmosphere absolute (ATA) for 60 min. Blood samples were collected before exercise (BE), after exercise (AE), and after HBOT (AH) to examine inflammation (fibrinogen, interleukin-6 [IL-6], and tumor necrosis factor-α (TNF-α)), the oxidative/antioxidant balance (derivatives of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP)), and muscle damage (creatine kinase (CK) and lactate dehydrogenase (LDH)). Plasma fibrinogen, serum IL-6, CK, and LDH levels were significantly increased AE compared to BE in all groups (p < 0.05). Plasma fibrinogen levels were significantly decreased AH compared to AE in all groups (p < 0.05), and the HNN group had a significantly lower AH compared to BE (p < 0.05). Serum IL-6 levels were significantly decreased AH compared to AE in the HNN and HHH groups (p < 0.05). Serum CK levels were significantly decreased AH compared to AE in the HHH group (p < 0.05). Serum LDH levels were significantly decreased AH compared to AE in the HNN and HHH groups (p < 0.05), and the NN and HNN groups had significantly higher AH serum LDH levels compared to BE (p < 0.05). These results suggest that acute exercise in both the NN and HH environments could induce temporary inflammatory responses and muscle damage, whereas HBOT treatment may be effective in alleviating exercise-induced inflammatory responses and muscle damage.
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