Brain stimulation over Broca's area differentially modulates naming skills in neurotypical adults and individuals with Asperger's syndrome.
Brain stimulation over Broca's area differentially modulates naming skills in neurotypical adults and individuals with Asperger's syndrome.
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DOI：
10.1111/j.1460-9568.2011.07726.x
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Pascual-Leone A
中科院分区：
文献类型：
--
作者：
Fecteau S;Agosta S;Oberman L;Pascual-Leone A
在目前的研究中，我们验证了一种假设，即在亚斯伯格综合征(ASP)患者中，语言相关区域的动态可能异常，因此重复的经颅磁刺激(RTMS)在布罗卡区会导致不同的行为效应，就像神经典型对照组中看到的那样。我们在10名ASP患者和10名年龄和性别匹配的健康受试者中进行了一项五点刺激、双盲、多交叉、伪随机、假对照研究。在每个个体的脑磁共振成像的立体定向指导下，在对左侧盖部、左侧三角部、右侧盖部和右侧三角部进行低频rTMS前后以及假刺激前后评估对象命名。在ASP参与者中，与假刺激相比，左侧三角部rTMS后的命名改善，而邻近左侧盖部的rTMS延长了命名潜伏期。在健康受试者中，刺激布罗卡区的部分区域并没有导致命名技能的显著变化，这与已发表的数据一致。总体而言，这些发现支持了我们关于ASP患者语言神经网络动力学异常的假说。从方法论的角度，这项工作说明了使用rTMS来研究脑-行为关系的动力学，揭示了非侵入性脑刺激在神经精神障碍中的不同行为影响。
In the present study we tested the hypothesis that, in subjects with Asperger’s syndrome (ASP), the dynamics of language-related regions might be abnormal, so that repetitive transcranial magnetic stimulation (rTMS) over Broca’s area leads to differential behavioral effects as seen in neurotypical controls. We conducted a five-stimulation-site, double-blind, multiple crossover, pseudo-randomized, sham-controlled study in 10 individuals with ASP and 10 age- and gender-matched healthy subjects. Object naming was assessed before and after low-frequency rTMS of the left pars opercularis, left pars triangularis, right pars opercularis and right pars triangularis, and sham stimulation, as guided stereotaxically by each individual’s brain magnetic resonance imaging. In ASP participants, naming improved after rTMS of the left pars triangularis as compared with sham stimulation, whereas rTMS of the adjacent left opercularis lengthened naming latency. In healthy subjects, stimulation of parts of Broca’s area did not lead to significant changes in naming skills, consistent with published data. Overall, these findings support our hypothesis of abnormal language neural network dynamics in individuals with ASP. From a methodological point of view, this work illustrates the use of rTMS to study the dynamics of brain–behavior relations by revealing the differential behavioral impact of non-invasive brain stimulation in a neuropsychiatric disorder.
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影响因子：
14.5
作者：
Just, MA;Cherkassky, VL;Minshew, NJ
通讯作者：
Minshew, NJ
DOI：
10.1098/rstb.2002.1209
发表时间：
2003-02-28
影响因子：
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影响因子：
1.5
作者：
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通讯作者：
Tager-Flusberg, H