Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.
Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.
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DOI：
10.1371/journal.pone.0036596
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Bourgeois C
中科院分区：
文献类型：
--
作者：
Simonetta F;Gestermann N;Martinet KZ;Boniotto M;Tissières P;Seddon B;Bourgeois C
调控外周CD4 + FOXP3 +调节性T细胞（Treg）存活和稳态的机制是多样的，这表明调节性T细胞稳态受到严格且复杂的调控。一些特定因子，如转化生长因子 - β、白细胞介素 - 2（IL - 2）和B7共刺激分子，已被确定为维持外周Treg细胞群所必需的。相反，Treg对经典的T细胞稳态因子如IL - 7的依赖性仍不清楚。在这项工作中，我们正式研究了IL - 7在小鼠模型体内Treg稳态中的作用。我们证明了IL - 7的可利用性调节外周Treg细胞池的大小，因此与IL - 7对常规T细胞池的影响相似。此外，我们表明IL - 7给药通过诱导不依赖胸腺的Treg外周扩增增加了Treg细胞数量。重要的是，无论是否存在常规T细胞，都能检测到IL - 7对Treg扩增的影响，因为在过继转移到淋巴细胞减少的宿主后，IL - 7直接参与Treg的外周扩增。我们的结果明确地将IL - 7确定为有助于Treg外周稳态的核心因素，从而在它们外周维持对IL - 7的需求方面将Treg与其他T细胞亚群相类比。
Mechanisms governing peripheral CD4+ FOXP3+ regulatory T cells (Treg) survival and homeostasis are multiple suggesting tight and complex regulation of regulatory T cells homeostasis. Some specific factors, such as TGF-β, interleukin-2 (IL-2) and B7 costimulatory molecules have been identified as essentials for maintenance of the peripheral Treg compartment. Conversely, Treg dependency upon classical T cell homeostatic factors such as IL-7 is still unclear. In this work, we formally investigated the role of IL-7 in Treg homeostasis in vivo in murine models. We demonstrated that IL-7 availability regulated the size of peripheral Treg cell pool and thus paralleled the impact of IL-7 on conventional T cell pool. Moreover, we showed that IL-7 administration increased Treg cell numbers by inducing thymic-independent Treg peripheral expansion. Importantly the impact of IL-7 on Treg expansion was detected whether conventional T cells were present or absent as IL-7 directly participates to the peripheral expansion of Treg after adoptive transfer into lymphopenic hosts. Our results definitively identify IL-7 as a central factor contributing to Treg peripheral homeostasis, thus reassembling Treg to other T cell subsets in respect of their need for IL-7 for their peripheral maintenance.
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CD127表达与FOXP3和人类CD4+ T Reg细胞的抑制功能成反比。
DOI：
10.1084/jem.20060772
发表时间：
2006-07-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
15.3
作者：
Bayer, AL;Yu, AX;Adeegbe, D;Malek, TR
通讯作者：
Malek, TR
DOI：
10.1084/jem.20030735
发表时间：
2003-12-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kondrack RM;Harbertson J;Tan JT;McBreen ME;Surh CD;Bradley LM
通讯作者：
Bradley LM
DOI：
10.4049/jimmunol.181.1.225
发表时间：
2008-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bayer AL;Lee JY;de la Barrera A;Surh CD;Malek TR
通讯作者：
Malek TR
影响因子：
32.4
作者：
Marie, Julien C.;Liggitt, Denny;Rudensky, Alexander Y.
通讯作者：
Rudensky, Alexander Y.