Ion/neutral, ion/electron, ion/photon, and ion/ion interactions in tandem mass spectrometry: do we need them all? Are they enough?
Ion/neutral, ion/electron, ion/photon, and ion/ion interactions in tandem mass spectrometry: do we need them all? Are they enough?
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DOI：
10.1007/s13361-010-0004-9
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发表时间：
2011-01
影响因子：
3.2
通讯作者：
Mentinova, Marija
中科院分区：
文献类型：
--
作者：
McLuckey, Scott A.;Mentinova, Marija
一系列的策略和工具已经开发出来，以方便通过串联质谱（MS/MS）测定感兴趣的分析物分子的初级结构。决定MS/MS谱中主要结构信息的两个主要因素是分析物分子产生的离子类型和解离方法。发生解离的离子类型取决于电离方法/条件和初始气相离子形成后可能发生的离子转化过程。此外，在质谱分析之前，可以通过衍生化反应扩大与分析物相关的离子类型的范围。解离方法包括那些简单地改变大量选择离子的内部状态的方法（即，像碰撞诱导解离的激活方法）以及依赖于解离之前离子类型转化的过程（例如，电子捕获解离）。为了研究离子解离和离子转化，人们研究了各种各样的离子相互作用，包括离子/中性、离子/光子、离子/电子和离子/离子相互作用。已经观察到各种各样的现象，其中许多已经作为结构分析的手段进行了探索/发展。从这些现象中产生的技术将在串联质谱法结构测定元素的背景下进行讨论，即离子类型定义和解离。强调了各种离子相互作用的独特方面以及广泛实施的任何障碍。
A range of strategies and tools has been developed to facilitate the determination of primary structures of analyte molecules of interest via tandem mass spectrometry (MS/MS). The two main factors that determine the primary structural information present in an MS/MS spectrum are the type of ion generated from the analyte molecule and the dissociation method. The ion-type subjected to dissociation is determined by the ionization method/conditions and ion transformation processes that might take place after initial gas-phase ion formation. Furthermore, the range of analyte-related ion types can be expanded via derivatization reactions prior to mass spectrometry. Dissociation methods include those that simply alter the population of internal states of the mass-selected ion (i.e., activation methods like collision-induced dissociation) as well as processes that rely on transformation of the ion-type prior to dissociation (e.g., electron capture dissociation). A variety of ionic interactions has been studied for the purpose of ion dissociation and ion transformation that include ion/neutral, ion/photon, ion/electron, and ion/ion interactions. A wide range of phenomena has been observed, many of which have been explored/developed as means for structural analysis. The techniques arising from these phenomena are discussed within the context of the elements of structure determination in tandem mass spectrometry, viz., ion-type definition and dissociation. Unique aspects of the various ion interactions are emphasized along with any barriers to widespread implementation.
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影响因子：
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