Awake replay of remote experiences in the hippocampus.
Awake replay of remote experiences in the hippocampus.
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DOI：
10.1038/nn.2344
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发表时间：
2009-07
影响因子：
25
通讯作者：
Frank, Loren M.
中科院分区：
文献类型：
--
作者：
Karlsson, Mattias P.;Frank, Loren M.
海马体重放被认为是巩固海马体-新皮层网络中事件记忆的必要条件。重放在睡眠和清醒时都存在，但睡眠重放涉及在没有特定感觉输入的情况下重新激活存储的表征，而清醒时的重放被认为依赖于当前环境的感觉输入。在这里，我们发现存储的表征在清醒和睡眠回放期间都被重新激活。我们发现大鼠海马位置细胞的序列在清醒时频繁重播。这种空间上的远程重放和对当前环境的局部重放一样普遍，而且与长时间的静止相比，动物最近处于运动状态时最强劲。这些结果表明，在清醒行为的短暂停顿中，海马体不断地重放过去的经历，这表明清醒重放在记忆巩固和检索中起着重要作用。
Hippocampal replay is thought to be essential for the consolidation of event memories in hippocampal–neocortical networks. Replay is present during both sleep and waking behavior, but while sleep replay involves the reactivation of stored representations in the absence of specific sensory inputs, awake replay is thought to depend on sensory input from the current environment. Here we show that stored representations are reactivated during both waking and sleep replay. We found frequent awake replay of sequences of rat hippocampal place cells from a previous experience. This spatially remote replay was as common as local replay of the current environment and was most robust when the animal had recently been in motion as compared to during extended periods of quiescence. These results indicate that the hippocampus consistently replays past experiences during brief pauses in waking behavior, suggesting a role for waking replay in memory consolidation and retrieval.
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影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G
影响因子：
2.5
作者：
Frank, LM;Brown, EN;Wilson, MA
通讯作者：
Wilson, MA
影响因子：
5.3
作者：
Karlsson, Mattias P.;Frank, Loren M.
通讯作者：
Frank, Loren M.
影响因子：
16.2
作者：
Frank, LM;Brown, EN;Wilson, M
通讯作者：
Wilson, M