Possible novel features of synaptic regulation during long-term facilitation in Aplysia.
Possible novel features of synaptic regulation during long-term facilitation in Aplysia.
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DOI：
10.1101/lm.053124.120
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Hawkins RD
中科院分区：
文献类型：
--
作者：
Jin I;Kassabov S;Kandel ER;Hawkins RD
大多数关于突触可塑性的分子机制的研究都集中在单个突触或细胞核的变化顺序上。然而，在分离的细胞培养物中，对失智症感觉神经元-运动神经元突触的长期易化的研究表明了易化的两个额外特征。首先，两个神经元之间的突触接触的数量也有调节，这可能发生在神经元乔木中细胞对特异性分支点的水平上。分支点包含许多参与蛋白质合成依赖性长期促进的分子，包括神经营养因子和RNA结合蛋白CPEB。第二，调节涉及稳态反馈，并且倾向于将两个神经元之间的接触总数保持在一个相当恒定的水平，无论是在休息时还是在易化后。这就提出了一个问题，即促进作用和内稳态如何共存。一个可能的答案是，他们都涉及自发传递和突触后Ca 2+，它可以有类似于LTP和LTD在海马的双向作用。此外，长期易化可能涉及稳态设定点的变化，这可能是由可塑性分子如CPEB和/或PKM编码的。基于这些思想的计算模型可以定性地模拟接触次数的促进和稳态的基本特征。
Most studies of molecular mechanisms of synaptic plasticity have focused on the sequence of changes either at individual synapses or in the cell nucleus. However, studies of long-term facilitation at Aplysia sensory neuron–motor neuron synapses in isolated cell culture suggest two additional features of facilitation. First, that there is also regulation of the number of synaptic contacts between two neurons, which may occur at the level of cell pair-specific branch points in the neuronal arbor. Branch points contain many molecules that are involved in protein synthesis-dependent long-term facilitation including neurotrophins and the RNA binding protein CPEB. Second, the regulation involves homeostatic feedback and tends to keep the total number of contacts between two neurons at a fairly constant level both at rest and following facilitation. That raises the question of how facilitation and homeostasis can coexist. A possible answer is suggested by the findings that they both involve spontaneous transmission and postsynaptic Ca2+, which can have bidirectional effects similar to LTP and LTD in hippocampus. In addition, long-term facilitation can involve a change in the set point of homeostasis, which could be encoded by plasticity molecules such as CPEB and/or PKM. A computational model based on these ideas can qualitatively simulate the basic features of both facilitation and homeostasis of the number of contacts.
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DOI：
10.1101/lm.043745.116
发表时间：
2017-01
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Farah CA;Hastings MH;Dunn TW;Gong K;Baker-Andresen D;Sossin WS
通讯作者：
Sossin WS
影响因子：
16.2
作者：
Choi YB;Li HL;Kassabov SR;Jin I;Puthanveettil SV;Karl KA;Lu Y;Kim JH;Bailey CH;Kandel ER
通讯作者：
Kandel ER
DOI：
10.1101/lm.031237.113
发表时间：
2013-09-18
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Hawkins RD
通讯作者：
Hawkins RD
DOI：
10.1098/rstb.2002.1254
发表时间：
2003-04-29
影响因子：
6.3
作者：
Harris, KM;Fiala, JC;Ostroff, L
通讯作者：
Ostroff, L
影响因子：
5.3
作者：
Ferguson, Larissa;Hu, Jiangyuan;Sossin, Wayne S.
通讯作者：
Sossin, Wayne S.