The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode.
The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode.
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DOI：
10.1186/gb-2014-15-3-r43
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发表时间：
2014-03-03
期刊：
影响因子：
12.3
通讯作者：
Urwin PE
中科院分区：
文献类型：
--
作者：
Cotton JA;Lilley CJ;Jones LM;Kikuchi T;Reid AJ;Thorpe P;Tsai IJ;Beasley H;Blok V;Cock PJ;Eves-van den Akker S;Holroyd N;Hunt M;Mantelin S;Naghra H;Pain A;Palomares-Rius JE;Zarowiecki M;Berriman M;Jones JT;Urwin PE
苍白球皮线虫是马铃薯作物的毁灭性病原，是最重要的经济作物寄生线虫之一。它也是胞囊线虫生物学的重要模式。孢囊线虫和根结线虫是两种最重要的植物寄生线虫类群，共同对全球粮食安全构成威胁。本文报道了G. pallida，连同转录组学数据，从大多数线虫的生活周期，特别是专注于生命周期阶段参与根入侵和建立的生物营养喂养网站。尽管与根结线虫的系统发育关系相对密切，但我们描述了两组之间非常不同的基因家族内容，特别是效应子库的广泛差异，包括G.苍白球，其中包括SPRYSEC家族的效应物。这突出了与根结线虫相比，孢囊线虫的独特生物学，到目前为止，根结线虫是唯一的基因组信息可用的定居植物寄生线虫。我们还提出了其他基因的剧目可能是重要的，在了解囊线虫的独特生物学和潜在的药物靶点和其他目标的控制深入的描述。我们提出的数据和分析将是利用后基因组方法开发急需的新策略来控制G。苍白球和相关病原体。
Globodera pallida is a devastating pathogen of potato crops, making it one of the most economically important plant parasitic nematodes. It is also an important model for the biology of cyst nematodes. Cyst nematodes and root-knot nematodes are the two most important plant parasitic nematode groups and together represent a global threat to food security. We present the complete genome sequence of G. pallida, together with transcriptomic data from most of the nematode life cycle, particularly focusing on the life cycle stages involved in root invasion and establishment of the biotrophic feeding site. Despite the relatively close phylogenetic relationship with root-knot nematodes, we describe a very different gene family content between the two groups and in particular extensive differences in the repertoire of effectors, including an enormous expansion of the SPRY domain protein family in G. pallida, which includes the SPRYSEC family of effectors. This highlights the distinct biology of cyst nematodes compared to the root-knot nematodes that were, until now, the only sedentary plant parasitic nematodes for which genome information was available. We also present in-depth descriptions of the repertoires of other genes likely to be important in understanding the unique biology of cyst nematodes and of potential drug targets and other targets for their control. The data and analyses we present will be central in exploiting post-genomic approaches in the development of much-needed novel strategies for the control of G. pallida and related pathogens.
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影响因子：
30.8
作者：
Desjardins, Christopher A.;Cerqueira, Gustavo C.;Goldberg, Jonathan M.;Hotopp, Julie C. Dunning;Haas, Brian J.;Zucker, Jeremy;Ribeiro, Jose M. C.;Saif, Sakina;Levin, Joshua Z.;Fan, Lin;Zeng, Qiandong;Russ, Carsten;Wortman, Jennifer R.;Fink, Doran L.;Birren, Bruce W.;Nutman, Thomas B.
通讯作者：
Nutman, Thomas B.
影响因子：
4
作者：
Behm, CA
通讯作者：
Behm, CA
影响因子：
4
作者：
Brown, L. A.;Jones, A. K.;Sattelle, D. B.
通讯作者：
Sattelle, D. B.
影响因子：
6.7
作者：
Baldacci-Cresp F;Chang C;Maucourt M;Deborde C;Hopkins J;Lecomte P;Bernillon S;Brouquisse R;Moing A;Abad P;Hérouart D;Puppo A;Favery B;Frendo P
通讯作者：
Frendo P
影响因子：
7
作者：
Allen, Mary Ann;Hillier, LaDeana W.;Blumenthal, Thomas
通讯作者：
Blumenthal, Thomas