Body mass index trajectories and the risk for Alzheimer's disease among older adults.
Body mass index trajectories and the risk for Alzheimer's disease among older adults.
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体重指数轨迹和老年人患阿尔茨海默氏病的风险。
DOI：
10.1038/s41598-021-82593-7
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发表时间：
2021-02-04
影响因子：
4.6
通讯作者：
Kim YS
中科院分区：
文献类型：
--
作者：
Kang SY;Kim YJ;Jang W;Son KY;Park HS;Kim YS
体重指数(BMI)的变化和变异性对阿尔茨海默病(AD)风险的影响仍不清楚。我们分析了45,076名参与者，他们的BMI是在韩国国家健康保险服务-健康筛查队列的第一阶段(2002-2003)、第二阶段(2004-2005)和第三阶段(2006-2007)测量的。我们使用COX回归模型评估了2年和4年的BMI变化和BMI变异性对AD风险的影响。在男性中，2年BMI变化、BMI变异性和AD风险之间的关联并不显著。体重指数在4年内下降10.1-15.0%的男性患AD的风险更高。在女性中，当两年体重指数下降5.1-10.0%、10.1-15.0%和 >； 15.0%时，AD的AHRS和95%CI分别为1.14(1.02-1.29)、1.44(1.17-1.79)和1.51(1.09-2.09)。当4年体重指数丢失 >； 为5.0%时，女性AD的危险比显著增加。AD的AHR和95%CI分别为1.31(1.17~1.46)和1.31(1.17~1.46)，与女性ASV的第1个四分位数相比。两年和四年期间BMI下降与AD风险增加相关，BMI变异性较高的女性风险增加。建议进行适当的体重管理，以预防AD。
The effect of body mass index (BMI) changes and variability on the risk for Alzheimer’s disease (AD) remains unclear. We analyzed 45,076 participants, whose BMI were measured on phase 1 (2002–2003), phase 2 (2004–2005), and phase 3 (2006–2007), of the Korean National Health Insurance Service-Health Screening Cohort. We evaluated the effect of 2- and 4-year BMI changes and BMI variability on the risk of AD using Cox regression models. In men, association between 2-year BMI changes, BMI variability, and the risk of AD was not significant. Risk of AD was higher in men whose BMI had decreased 10.1–15.0% over 4 years. In women, aHRs and 95% CIs for AD were 1.14 (1.02–1.29), 1.44 (1.17–1.79), and 1.51 (1.09–2.09) when 2-year BMI loss was 5.1–10.0%, 10.1–15.0%, and > 15.0%. The HRs for AD in women significantly increased when 4-year BMI loss was > 5.0%. The aHR and 95% CI for AD was 1.31 (1.17–1.46) in the 4th quartile of average successive variability (ASV) compared with the 1st quartile of ASV in women. BMI loss over 2- and 4-year period was associated with increased risk for AD, and risk increased in women with higher BMI variability. Appropriate body weight management is recommended to prevent AD.
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影响因子：
120.7
作者：
Lieb, Wolfgang;Beiser, Alexa S.;Vasan, Ramachandran S.;Tan, Zaldy S.;Au, Rhoda;Harris, Tamara B.;Roubenoff, Ronenn;Auerbach, Sanford;DeCarli, Charles;Wolf, Philip A.;Seshadri, Sudha
通讯作者：
Seshadri, Sudha
影响因子：
1.6
作者：
Kang HG;Park HY;Ryu HU;Suk SH
通讯作者：
Suk SH
影响因子：
4.7
作者：
Loskutova, Natalia;Watts, Amber S.;Burns, Jeffrey M.
通讯作者：
Burns, Jeffrey M.
影响因子：
6
作者：
Kashihara, Kenichi
通讯作者：
Kashihara, Kenichi
影响因子：
6.3
作者：
Koller D;Hua T;Bynum JP
通讯作者：
Bynum JP