Regulation of metabolic networks by small molecule metabolites.
Regulation of metabolic networks by small molecule metabolites.
复制标题
DOI：
10.1186/1471-2105-8-88
复制
发表时间：
2007-03-13
影响因子：
3
通讯作者：
Goto S
中科院分区：
文献类型：
--
作者：
Gutteridge A;Kanehisa M;Goto S
调节新陈代谢的能力是生命系统中的一个基本过程。我们对代谢调节发生的机制之一进行了分析：小分子的酶抑制和激活。我们看看这个调控系统的网络特性和调控分子的化学性质之间的关系。我们发现，许多功能的监管网络，如度和聚类系数，密切匹配的基础代谢网络。虽然这些全局特征在几种生物中是保守的，但我们确实发现了E. coli和H.反映了他们不同的生活方式。化学结构似乎在确定化合物是否适合用于监管方面起着重要作用。化学结构通常也决定了类似化合物如何调节酶。这些化合物和它们调节的酶形成模块，反映了潜在代谢网络的模块和途径。我们还展示了化学结构和调控的知识如何用于预测药物的调控相互作用。代谢调控网络具有代谢网络的许多全局特性，但通常在单个化合物的水平上变化。化学结构是决定化合物如何用于调控和定义调控系统内模块的关键决定因素。
The ability to regulate metabolism is a fundamental process in living systems. We present an analysis of one of the mechanisms by which metabolic regulation occurs: enzyme inhibition and activation by small molecules. We look at the network properties of this regulatory system and the relationship between the chemical properties of regulatory molecules. We find that many features of the regulatory network, such as the degree and clustering coefficient, closely match those of the underlying metabolic network. While these global features are conserved across several organisms, we do find local differences between regulation in E. coli and H. sapiens which reflect their different lifestyles. Chemical structure appears to play an important role in determining a compounds suitability for use in regulation. Chemical structure also often determines how groups of similar compounds can regulate sets of enzymes. These groups of compounds and the enzymes they regulate form modules that mirror the modules and pathways of the underlying metabolic network. We also show how knowledge of chemical structure and regulation could be used to predict regulatory interactions for drugs. The metabolic regulatory network shares many of the global properties of the metabolic network, but often varies at the level of individual compounds. Chemical structure is a key determinant in deciding how a compound is used in regulation and for defining modules within the regulatory system.
登录
查看更多内容
影响因子：
56.9
作者：
Milo, R;Shen-Orr, S;Alon, U
通讯作者：
Alon, U
影响因子：
56.9
作者：
Barabási, AL;Albert, R
通讯作者：
Albert, R
影响因子：
14.9
作者：
Goto, S;Okuno, Y;Kanehisa, M
通讯作者：
Kanehisa, M
影响因子：
64.8
作者：
Jeong, H;Tombor, B;Barabási, AL
通讯作者：
Barabási, AL
影响因子：
56.9
作者：
Ravasz, E;Somera, AL;Barabási, AL
通讯作者：
Barabási, AL