A Monte Carlo study of fluorescence generation probability in a two-layered tissue model
A Monte Carlo study of fluorescence generation probability in a two-layered tissue model
复制标题
两层组织模型中荧光产生概率的蒙特卡罗研究
DOI：
--
复制
发表时间：
2014
影响因子：
3.5
通讯作者：
A. Liebert
中科院分区：
文献类型：
--
作者：
Daniel Milej;A. Gerega;H. Wabnitz;A. Liebert
最近有报道称，在注射光学造影剂期间漫反射和/或荧光的时间分辨测量可构成评估脑灌注的技术的基础。在本文中，我们提出了模拟内和脑外组织腔室的双层组织模型中的激发光子和荧光光子的跟踪的传播的Monte Carlo模拟结果。空间3D分布的概率，光子被转换从激发到发射波长在一个定义的体素的介质（生成概率），在他们之间的源和检测器的旅行获得不同的光学特性在脑内和脑外组织隔间。注意到生成概率的空间分布取决于介质中荧光团的分布，并且受介质和荧光团在激发和发射波长处的吸收的影响。还对两层中染料浓度的真实时间过程进行了模拟。研究的结果表明，在激发和发射波长的介质的吸收特性的知识是必不可少的时间分辨的荧光信号的头部的表面上测量的解释。
It was recently reported that the time-resolved measurement of diffuse reflectance and/or fluorescence during injection of an optical contrast agent may constitute a basis for a technique to assess cerebral perfusion. In this paper, we present results of Monte Carlo simulations of the propagation of excitation photons and tracking of fluorescence photons in a two-layered tissue model mimicking intra- and extracerebral tissue compartments. Spatial 3D distributions of the probability that the photons were converted from excitation to emission wavelength in a defined voxel of the medium (generation probability) during their travel between source and detector were obtained for different optical properties in intra- and extracerebral tissue compartments. It was noted that the spatial distribution of the generation probability depends on the distribution of the fluorophore in the medium and is influenced by the absorption of the medium and of the fluorophore at excitation and emission wavelengths. Simulations were also carried out for realistic time courses of the dye concentration in both layers. The results of the study show that the knowledge of the absorption properties of the medium at excitation and emission wavelengths is essential for the interpretation of the time-resolved fluorescence signals measured on the surface of the head.
影响因子：
1.9
作者：
Srinivasan, S;Pogue, BW;Paulsen, KD
通讯作者：
Paulsen, KD
影响因子：
3.8
作者：
Intes, X;Ripoll, J;Chance, B
通讯作者：
Chance, B