The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration.
The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration.
复制标题
时间的流逝：衰老，炎症，氧化应激和神经退行性疾病的生物钟。
DOI：
10.1016/j.nbd.2020.104832
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发表时间：
2020-06
影响因子：
6.1
通讯作者：
Musiek ES
中科院分区：
文献类型：
--
作者：
Lananna BV;Musiek ES
A substantial body of research now implicates the circadian clock in the regulation of an array of diverse biological processes including glial function, metabolism, peripheral immune responses, and redox homeostasis. Sleep abnormalities and other forms of circadian disruption are common symptoms of aging and neurodegeneration. Circadian clock disruption may also influence the aging processes and the pathogenesis of neurodegenerative diseases. The specific mechanisms governing the interaction between circadian systems, aging, and the immune system are still being uncovered. Here, we will review the evidence supporting a bidirectional relationship between aging and the circadian system. Further, we explore the hypothesis that age-related circadian deterioration may exacerbate multiple pathogenic processes, priming the brain for neurodegeneration.
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影响因子：
16.2
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Cao R;Robinson B;Xu H;Gkogkas C;Khoutorsky A;Alain T;Yanagiya A;Nevarko T;Liu AC;Amir S;Sonenberg N
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影响因子：
16.6
作者：
Barca-Mayo O;Pons-Espinal M;Follert P;Armirotti A;Berdondini L;De Pietri Tonelli D
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De Pietri Tonelli D
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4.2
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DEMENT, WC
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5.1
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Kilic, Ertugrul