MicroRNAs: critical mediators of differentiation, development and disease.
MicroRNAs: critical mediators of differentiation, development and disease.
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DOI：
10.4414/smw.2009.12794
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发表时间：
2009-08-22
影响因子：
2.9
通讯作者：
Jones PA
中科院分区：
文献类型：
--
作者：
Friedman JM;Jones PA
microRNA（miRNAs）是一种在高等真核生物中表达的小的非编码RNA，甚至在病毒基因组中也有发现。它们通常通过抑制翻译、引起mRNA降解或通过两种机制的组合作为靶基因的内源性阻遏物。在人类中已经鉴定了超过850种成熟的miRNA序列，尽管这占人类基因的不到2%，但预测30%的mRNA被miRNA靶向。miRNA在大多数细胞过程中起关键作用，包括细胞和生物体的发育、分化和稳态。此外，许多疾病状态，包括癌症，发生或持续的miRNA失调。在这里，我们将审查的最新报告的miRNA参与和异常表达的人类疾病，重点是癌症。
MicroRNAs (miRNAs) are small non-coding RNAs that are expressed in higher eukaryoates and have even been found in viral genomes. They usually act as endogenous repressors of target genes by either inhibiting translation, causing mRNA degradation, or by a combination of both mechanisms. More than 850 mature miRNA sequences have been identified in humans, and although this accounts for less than 2% of human genes, it is predicted that 30% of mRNAs are targeted by miRNAs. miRNAs play critical roles in most cellular processes including development, differentiation, and the homeostasis of both a cell and an organism. Moreover, many disease states, including cancer, occur or are sustained by miRNA dysregulation. Here we will review the latest reports of miRNA involvement and aberrant expression in human disease with an emphasis on cancer.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
64.5
作者：
Eulalio, Ana;Huntzinger, Eric;Izaurralde, Elisa
通讯作者：
Izaurralde, Elisa
影响因子：
56.9
作者：
Farh, KKH;Grimson, A;Bartel, DP
通讯作者：
Bartel, DP
影响因子：
82.9
作者：
Bonci, Desiree;Coppola, Valeria;De Maria, Ruggero
通讯作者：
De Maria, Ruggero
DOI：
10.1073/pnas.0602266103
发表时间：
2006-05-02
影响因子：
11.1
作者：
Costinean, S;Zanesi, N;Croce, CM
通讯作者：
Croce, CM