Role of the Extracellular Matrix in Alzheimer's Disease.

Role of the Extracellular Matrix in Alzheimer's Disease.
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细胞外基质在阿尔茨海默病中的作用

DOI:
10.3389/fnagi.2021.707466
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发表时间:
2021
影响因子:
4.8
通讯作者:
Yang Q
Yang Q
中科院分区:
医学2区
文献类型:
--
作者:
Sun Y;Xu S;Jiang M;Liu X;Yang L;Bai Z;Yang Q

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Alzheimer’s disease (AD) is a neurodegenerative disease with complex pathological characteristics, whose etiology and pathogenesis are still unclear. Over the past few decades, the role of the extracellular matrix (ECM) has gained importance in neurodegenerative disease. In this review, we describe the role of the ECM in AD, focusing on the aspects of synaptic transmission, amyloid-β-plaque generation and degradation, Tau-protein production, oxidative-stress response, and inflammatory response. The function of ECM in the pathological process of AD will inform future research on the etiology and pathogenesis of AD.
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