Regional cerebral glucose metabolism during and after bilateral cerebral ischemia in the gerbil.
Regional cerebral glucose metabolism during and after bilateral cerebral ischemia in the gerbil.
复制标题
沙鼠双侧脑缺血期间和之后的局部脑葡萄糖代谢。
DOI：
10.1161/01.str.14.4.568
复制
发表时间：
1983
期刊：
影响因子：
8.3
通讯作者：
Reivich,M
中科院分区：
文献类型：
--
作者：
Choki,J;Greenberg,J;Reivich,M
采用14 C-脱氧葡萄糖技术，在沙土鼠双侧颈总动脉闭塞的中风模型中测量脑葡萄糖代谢率（CMRG）。在30分钟的缺血，14 C-脱氧葡萄糖摄取在脑中增加沿着缺血和非缺血区之间的边界区和减少在缺血区。在再灌注早期（2或3 ~ 30分钟），大脑皮质、尾壳核和丘脑的CMRG增加50 ~ 150%，海马、苍白球和杏仁核的CMRG增加270 ~ 320%。再灌注后期（15 ~ 45分钟），大脑皮质、尾壳核和丘脑的CMRG出现不均一性。在大脑皮层中，CMRG降低至低于对照值的50%，但在海马、苍白球和杏仁核中保持在对照值的200 - 300%。后者的结构表现出更大和更持久的葡萄糖代谢增加比其他结构最可能是由于这些结构的缺血的组织学脆弱性。讨论了葡萄糖代谢的瞬时增加与细胞功能之间的关系。
Cerebral metabolic rate for glucose (CMRG) was measured using the 14C-deoxyglucose technique in a stroke model of the gerbil produced by bilateral common carotid artery occlusion. During 30 minutes of ischemia, 14C-deoxyglucose uptake in the brain was increased along the border zone between the ischemic and nonischemic area and decreased in the ischemic areas. During the early stage of reperfusion (2 or 3 to 30 minutes), CMRG increased 50 to 150% in the cerebral cortex, caudoputamen and thalamus and 270 to 320% in the hippocampus, globus pallidus and amygdala. During the late stage of reperfusion (15 to 45 minutes), heterogeneity of CMRG appeared in the cerebral cortex, caudoputamen and thalamus. CMRG decreased to less than 50% of the control value in the cerebral cortex but remained at 200 to 300% of control in the hippocampus, globus pallidus and amygdala. The latter structures exhibited a larger and more protracted increase in glucose metabolism than the other structures most probably due to the histological vulnerability to ischemia of these structures. The relationship between the transient increase of the glucose metabolism and cell function is discussed.
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