Genome-wide association study (GWAS) for growth rate and age at sexual maturation in Atlantic salmon (Salmo salar).
Genome-wide association study (GWAS) for growth rate and age at sexual maturation in Atlantic salmon (Salmo salar).
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全基因组协会研究（GWAS）关于大西洋鲑鱼（Salmo Salar）性成熟时的增长率和年龄。
DOI：
10.1371/journal.pone.0119730
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Davidson WS
中科院分区：
文献类型：
--
作者：
Gutierrez AP;Yáñez JM;Fukui S;Swift B;Davidson WS
性成熟过早被认为是大西洋鲑鱼水产养殖的一个严重缺点，因为它阻碍生长，增加生产时间并影响肉质。虽然生长和性成熟被认为是由几个遗传和环境因素控制的复杂过程，但自大西洋鲑鱼选择性育种计划开始以来，这些性状的选择一直在不断完成。在这项全基因组关联研究（GWAS）中，我们使用6.5K单核苷酸多态性（SNP）阵列对来自Cermaq加拿大亲鱼计划的1480个个体进行基因分型，并寻找与性成熟时的生长和年龄相关的SNP。使用混合模型的方法，我们确定了标记显示与生长，grilsing（早期性成熟）和性成熟后期显着相关。最显着的协会被发现为grilsing，标记位于Ssa10，Ssa02，Ssa13，Ssa25和Ssa12，并为晚成熟标记位于Ssa28，Ssa01和Ssa21。在Ssa 13上检测到与生长的较低水平的关联。与这些遗传标记相关的候选基因被鉴定出来，其中一些基因与发育过程有直接关系，特别是与性成熟相关的基因。然而，相对较低的功率来检测与生长（天至5公斤）在这个GWAS的遗传标记表明，需要使用更高密度的SNP阵列，以克服低水平的连锁不平衡观察大西洋鲑鱼之前，信息可以被纳入选择性育种计划。
Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors, selection for these traits has been continuously accomplished since the beginning of Atlantic salmon selective breeding programs. In this genome-wide association study (GWAS) we used a 6.5K single-nucleotide polymorphism (SNP) array to genotype ∼480 individuals from the Cermaq Canada broodstock program and search for SNPs associated with growth and age at sexual maturation. Using a mixed model approach we identified markers showing a significant association with growth, grilsing (early sexual maturation) and late sexual maturation. The most significant associations were found for grilsing, with markers located in Ssa10, Ssa02, Ssa13, Ssa25 and Ssa12, and for late maturation with markers located in Ssa28, Ssa01 and Ssa21. A lower level of association was detected with growth on Ssa13. Candidate genes, which were linked to these genetic markers, were identified and some of them show a direct relationship with developmental processes, especially for those in association with sexual maturation. However, the relatively low power to detect genetic markers associated with growth (days to 5 kg) in this GWAS indicates the need to use a higher density SNP array in order to overcome the low levels of linkage disequilibrium observed in Atlantic salmon before the information can be incorporated into a selective breeding program.
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影响因子：
3.8
作者：
Eisbrenner WD;Botwright N;Cook M;Davidson EA;Dominik S;Elliott NG;Henshall J;Jones SL;Kube PD;Lubieniecki KP;Peng S;Davidson WS
通讯作者：
Davidson WS
DOI：
10.1186/1297-9686-42-17
发表时间：
2010-06-04
期刊：
Genetics, selection, evolution : GSE
影响因子：
--
作者：
Baranski M;Moen T;Våge DI
通讯作者：
Våge DI
影响因子：
4.5
作者：
GJERDE, B
通讯作者：
GJERDE, B
影响因子：
4.5
作者：
GJEDREM, T;GJOEN, HM;GJERDE, B
通讯作者：
GJERDE, B
影响因子：
5.8
作者：
Gidskehaug, Lars;Kent, Matthew;Lien, Sigbjorn
通讯作者：
Lien, Sigbjorn