Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC)

Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC)
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成人肺高级别神经内分泌癌 (HGNEC) 发生第二原发恶性肿瘤的风险

DOI:
10.1186/s12885-020-07224-2
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发表时间:
2020-08
期刊:
影响因子:
3.8
通讯作者:
Ping Chen
Ping Chen
中科院分区:
医学2区
文献类型:
--
作者:
Xiaomin Wu;Xiaojing Zhang;Leilei Tao;Ping Chen

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背景肺高级别神经内分泌癌(HGNEC)发展为第二原发恶性肿瘤(SPM)的发病率不断上升。这项研究是第一个基于人群的分析,以量化肺HGNEC.MethodsWe使用的监测,流行病学和最终结果(SEER)数据库的幸存者SPM风险计算标准化发病率比(SIR)和绝对超额风险(AER)之间2000年和2016年肺HGNEC.ResultsThe数据的1161例SPM患者从SEER数据库检索。肺HGNEC中SPM的观察/预期数量比值为1.53。实体瘤占肺部HGNEC患者所有第二恶性肿瘤的91%,最常见的癌症报告在口腔和咽部,泌尿和呼吸系统ConclusionsOur研究观察到肺部肿瘤患者中SPM的风险增加。
BackgroundPulmonary high-grade neuroendocrine carcinoma (HGNEC) has a rising incidence of developing second primary malignancies (SPMs). This study is the first population-based analysis to quantify the SPM risks among survivors of lung HGNEC.MethodsWe used the Surveillance, Epidemiology, and End Results (SEER) database to calculate standardized incidence ratio (SIR) and absolute excess risk (AER) between 2000 and 2016 for patients with pulmonary HGNEC.ResultsThe data of 1161 patients with SPMs were retrieved from the SEER database. The ratio of observed/expected number of SPMs in pulmonary HGNEC was 1.53. Solid tumours comprised 91% of all second malignancies in lung HGNEC patients, with the most common cancers reported in the oral cavity and pharynx, the urinary and respiratory systemsConclusionsOur study observed an increased risk of SPMs among patients with pulmongnancies.
DOI: 10.1093/pcmedi/pbac012
发表时间: 2022-05-13
影响因子: 5.3
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DOI: 10.1038/s41598-017-01571-0
发表时间: 2017-05-02
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