The fellowship of regulatory and tissue-resident memory cells.
The fellowship of regulatory and tissue-resident memory cells.
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DOI：
10.1038/s41385-021-00456-w
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发表时间：
2022-01
影响因子：
8
通讯作者：
Veldhoen M
中科院分区：
文献类型：
--
作者：
Barros L;Ferreira C;Veldhoen M
近年来，位于非淋巴组织中的T细胞变得突出。CD8+组织驻留记忆（Trm）细胞对于组织免疫监视是重要的，提供了抵抗入侵病原体的重要防线，并在癌症治疗中显示出前景。这些细胞在表型上与其他记忆群体不同，适应于它们发现其同源抗原的组织，并且具有不同的存活和激活代谢要求。CD4+ Foxp3+调节性T（Treg）细胞也由在非淋巴组织中发现的具有不同转录程序的特化群体组成。这些细胞同样适应了在它们安家的组织中发挥作用。Trm和Treg细胞都具有超出免疫防御的功能，涉及组织稳态，修复和周转。它们是多细胞通讯网络的一部分。有趣的是，占据相同的生态位，Treg细胞在Trm细胞的建立中很重要，这可能对利用Trm细胞的免疫监视和组织稳态特性用于未来的治疗具有意义。
T cells located in non-lymphoid tissues have come to prominence in recent years. CD8+ tissue-resident memory (Trm) cells are important for tissue immune surveillance, provide an important line of defence against invading pathogens and show promise in cancer therapies. These cells differ in phenotype from other memory populations, are adapted to the tissue they home to where they found their cognate antigen and have different metabolic requirements for survival and activation. CD4+ Foxp3+ regulatory T (Treg) cells also consist of specialised populations, found in non-lymphoid tissues, with distinct transcriptional programmes. These cells have equally adapted to function in the tissue they made their home. Both Trm and Treg cells have functions beyond immune defence, involving tissue homeostasis, repair and turnover. They are part of a multicellular communication network. Intriguingly, occupying the same niche, Treg cells are important in the establishment of Trm cells, which may have implications to harness the immune surveillance and tissue homeostasis properties of Trm cells for future therapies.
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影响因子：
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