S100β in newborns after C-section with general vs. epidural anesthesia: a prospective observational study.
S100β in newborns after C-section with general vs. epidural anesthesia: a prospective observational study.
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DOI：
10.1111/aas.13038
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发表时间：
2018-03
影响因子：
2.1
通讯作者：
Wei H
中科院分区：
文献类型：
--
作者：
Xu Z;Liu Z;Zhang Y;Jin C;Shen F;Yu Y;Cheek T;Onuoha O;Liang G;Month R;Atkins J;Tran KM;Wei H
临床前证据表明，全身麻醉剂可以剂量依赖性地诱导动物发育中大脑的神经变性，这可以通过测量血液S100β可靠地确定，但这种相关性在人类中仍不清楚。我们假设，与硬膜外麻醉相比，在剖腹产期间短暂暴露于全身麻醉剂的胎儿的脐带动脉血中S100β不会增加。一项前瞻性观察性临床研究比较了硬膜外麻醉或全身麻醉下剖腹产后即刻脐动脉与静脉的脑损伤生物标志物S100β比值（胎儿循环后的变化）的变化。新生儿血气测量，APGAR评分和母亲的幸福感也进行了比较。与硬膜外麻醉相比，全身麻醉导致脐动脉与静脉的S100β比值较低（中位数2.64，[四分位数1.39，3.45] vs.中位数1.59，[四分位数0.88，2.01]，P=0.031），而不改变母亲静脉中的S100β水平。在比较其他产妇和新生儿参数时，全麻和硬膜外麻醉之间无显著差异。全麻下剖宫产新生儿血清S100β水平低于硬膜外麻醉，其机制尚不清楚。
Preclinical evidence suggests that general anesthetics can dose-dependently induce neurodegeneration in the developing brains of animals which can be reliably determined by measurement of blood S100β, but this correlation remains unclear in humans. We hypothesized that S100β would not be increased in cord arterial blood of fetuses exposed briefly to general anesthetics during a C-section, compared to epidural anesthesia. A prospective observational clinical study comparatively measured changes of brain damage biomarker S100β ratio of umbilical artery over vein (changes after fetus circulation) immediately after delivery under C-section with either epidural or general anesthesia. Newborn blood gas measurements, APGAR scores and maternal wellbeing were also compared. Compared to epidural anesthesia, general anesthesia resulted in the lower S100β ratio of umbilical artery over the vein (medium 2.64, [quartiles 1.39, 3.45] vs. medium 1.59, [quartiles 0.88, 2.01], P=0.031), without changing the S100β level in the vein of the mother. There was no significant difference between general and epidural anesthesia when comparing other maternal and newborn parameters. S100β levels in newborn after C-section is lower with general anesthesia than epidural anesthesia, with unclear mechanisms.
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影响因子：
8.8
作者：
Sprung J;Flick RP;Wilder RT;Katusic SK;Pike TL;Dingli M;Gleich SJ;Schroeder DR;Barbaresi WJ;Hanson AC;Warner DO
通讯作者：
Warner DO
影响因子：
8.2
作者：
Kawata, Keisuke;Liu, Charles Y.;Merkel, Steven F.;Ramirez, Servio H.;Tierney, Ryan T.;Langford, Dianne
通讯作者：
Langford, Dianne
DOI：
10.1016/s0140-6736(15)00608-x
发表时间：
2016-01-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Davidson AJ;Disma N;de Graaff JC;Withington DE;Dorris L;Bell G;Stargatt R;Bellinger DC;Schuster T;Arnup SJ;Hardy P;Hunt RW;Takagi MJ;Giribaldi G;Hartmann PL;Salvo I;Morton NS;von Ungern Sternberg BS;Locatelli BG;Wilton N;Lynn A;Thomas JJ;Polaner D;Bagshaw O;Szmuk P;Absalom AR;Frawley G;Berde C;Ormond GD;Marmor J;McCann ME;GAS consortium
通讯作者：
GAS consortium
影响因子：
5.7
作者：
Bickler, Philip E.;Fahlman, Christian S.
通讯作者：
Fahlman, Christian S.
影响因子：
5.7
作者：
Peng J;Drobish JK;Liang G;Wu Z;Liu C;Joseph DJ;Abdou H;Eckenhoff MF;Wei H
通讯作者：
Wei H