Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device.
Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device.
复制标题
DOI：
10.1039/c2lc21156d
复制
发表时间：
2012-05-07
期刊：
影响因子：
6.1
通讯作者：
Borenstein JT
中科院分区：
文献类型：
--
作者：
Kniazeva T;Epshteyn AA;Hsiao JC;Kim ES;Kolachalama VB;Charest JL;Borenstein JT
微流控制造技术正在成为体外肺辅助设备和氧合器的可行平台，用于心脏外科支持和重症监护医学，部分原因是它们能够比现有技术更接近地模拟人类血管的结构。与目前的中空纤维氧合器技术相比，微流控系统具有更具生理学代表性的血流路径、更小的横截面血液管道和更薄的气体传输膜。这些功能可以实现更小的设备尺寸和氧合器中的血容量，增强气体传输效率，还可以减少系统中的凝结倾向。需要解决几个关键问题，以便将这项技术从目前的状态推进到临床使用的器官规模的设备中。在这里，我们报道了多层微流控氧合器的设计、制造和表征，研究了多层器件中与流体机械阻力、氧传递效率和其他参数相关的结垢效应。随着器件向多层方向扩展，互连的流体阻力等重要参数变得更加重要，而膜膨胀性等其他影响变得不那么显著。本研究还探讨了血液通道深度和膜厚度对氧传递的关系，以及氧传递速率对装置中的层数的影响。这些结果有助于我们理解设计临床应用的三维微流控氧合器所涉及的复杂性。
Microfluidic fabrication technologies are emerging as viable platforms for extracorporeal lung assist devices and oxygenators for cardiac surgical support and critical care medicine, based in part on their ability to more closely mimic the architecture of the human vasculature than existing technologies. In comparison with current hollow fiber oxygenator technologies, microfluidic systems have more physiologically-representative blood flow paths, smaller cross section blood conduits and thinner gas transfer membranes. These features can enable smaller device sizes and a reduced blood volume in the oxygenator, enhanced gas transfer efficiencies, and may also reduce the tendency for clotting in the system. Several critical issues need to be addressed in order to advance this technology from its current state and implement it in an organ-scale device for clinical use. Here we report on the design, fabrication and characterization of multilayer microfluidic oxygenators, investigating scaling effects associated with fluid mechanical resistance, oxygen transfer efficiencies, and other parameters in multilayer devices. Important parameters such as the fluidic resistance of interconnects are shown to become more predominant as devices are scaled towards many layers, while other effects such as membrane distensibility become less significant. The present study also probes the relationship between blood channel depth and membrane thickness on oxygen transfer, as well as the rate of oxygen transfer on the number of layers in the device. These results contribute to our understanding of the complexity involved in designing three-dimensional microfluidic oxygenators for clinical applications.
登录
查看更多内容
DOI：
10.1186/cc8213
发表时间：
2009
期刊：
Critical care (London, England)
影响因子：
--
作者：
Müller T;Philipp A;Luchner A;Karagiannidis C;Bein T;Hilker M;Rupprecht L;Langgartner J;Zimmermann M;Arlt M;Wenger J;Schmid C;Riegger GA;Pfeifer M;Lubnow M
通讯作者：
Lubnow M
影响因子：
6.1
作者：
Lim, D;Kamotani, Y;Takayama, S
通讯作者：
Takayama, S
影响因子：
10
作者：
Bellan, Leon M.;Kniazeva, Tatiana;Kim, Ernest S.;Epshteyn, Alla A.;Cropek, Donald M.;Langer, Robert;Borenstein, Jeffrey T.
通讯作者：
Borenstein, Jeffrey T.
DOI：
10.1126/science.1188302
发表时间：
2010-06-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Huh D;Matthews BD;Mammoto A;Montoya-Zavala M;Hsin HY;Ingber DE
通讯作者：
Ingber DE
影响因子：
3.7
作者：
Kolachalama VB;Levine EG;Edelman ER
通讯作者：
Edelman ER