Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.
Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.
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DOI：
10.1002/adhm.201100052
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发表时间：
2012-03
影响因子：
10
通讯作者：
Borenstein, Jeffrey T.
中科院分区：
文献类型：
--
作者：
Bellan, Leon M.;Kniazeva, Tatiana;Kim, Ernest S.;Epshteyn, Alla A.;Cropek, Donald M.;Langer, Robert;Borenstein, Jeffrey T.
虽然二维微流体系统的制造已经成为标准化的、直接的过程，但是真正的三维微流体系统的制造仍然极具挑战性。然而，对于三维微流体结构，特别是对于组织工程应用，存在日益增长的需求，并且已经开发了几种技术来满足这种需求。这些技术的范围从使用复杂的技术，如固体自由成形制造[1]-[3]到更简单的方法，如编织[4]或利用多层光刻图案化的二维流体结构。已经采用多层堆叠技术，其中多层二维微流体网络组装在具有垂直连接通孔的垂直堆叠中，因为它利用了光刻2D微流体的高分辨率能力，不需要额外的硬件，并且相对简单。该技术已用于形成诸如器官辅助装置、[5][7]微血管网络和生物相容性、不可降解性和生物相容性的体外模型等应用的装置。
While fabrication of two-dimensional microfluidic systems has become a standardized, straightforward process, fabrication of true three dimensional microfluidic systems remains extremely challenging. There is an increasing demand, however, for three dimensional microfluidic architectures, particularly for tissue engineering applications, and several techniques have been developed to address this need. These techniques range from using complex techniques, such as solid freeform fabrication,[1]–[3] to simpler approaches such as weaving [4] or making use of multiple layers of lithographically patterned two dimensional fluidic structures. The multi-layer stacking technique, in which multiple layers of two dimensional microfluidic networks are assembled in a vertical stack with vertical connecting vias, has been adopted because it leverages the high-resolution capabilities of lithographic 2D microfluidics, requires no additional hardware, and is relatively straightforward. This technique has been used to form devices for applications such as organ assist devices,[5][7] microvascular networks and in vitro models in both biocompatible, nondegradable
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影响因子：
14
作者：
Mata, Alvaro;Kim, Eun Jung;Boehm, Cynthia A.;Fleischman, Aaron J.;Muschler, George F.;Roy, Shuvo
通讯作者：
Roy, Shuvo
影响因子：
2.7
作者：
Marentis, Theodore C.;Vacanti, Joseph P.;Borenstein, Jeffrey T.
通讯作者：
Borenstein, Jeffrey T.
影响因子：
29.4
作者：
Wu, Willie;DeConinck, Adam;Lewis, Jennifer A.
通讯作者：
Lewis, Jennifer A.
影响因子：
--
作者：
Fidkowski, C;Kaazempur-Mofrad, MR;Wang, YD
通讯作者：
Wang, YD
影响因子：
3.4
作者：
Bellan, Leon M.;Singh, Sunil P.;Spector, Jason A.
通讯作者：
Spector, Jason A.