Microbiota-antibody interactions that regulate gut homeostasis.

Microbiota-antibody interactions that regulate gut homeostasis.
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DOI:
10.1016/j.chom.2021.02.009
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发表时间:
2021-03-10
影响因子:
30.3
通讯作者:
Round JL
Round JL
中科院分区:
医学1区
文献类型:
--
作者:
Weis AM;Round JL

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Immunoglobulin A (IgA) is the most abundant antibody at mucosal surfaces and has been the subject of many investigations involving microbiota research in the last decade. While the classic functions of IgA include neutralization of harmful toxins, more recent investigations have highlighted an important role for IgA in regulating the composition and function of the commensal microbiota. Multiple reviews have comprehensively covered the literature that describes recent, novel mechanisms of action of IgA and development of the IgA response within the intestine. Here we focus on how the interaction between IgA and the microbiota promotes homeostasis with the host to prevent disease.
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