Investigation of iterative image reconstruction in low-dose breast CT.

Investigation of iterative image reconstruction in low-dose breast CT.
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DOI:
10.1088/0031-9155/59/11/2659
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发表时间:
2014-06-07
影响因子:
3.5
通讯作者:
Pan X
Pan X
中科院分区:
工程技术2区
文献类型:
--
作者:
Bian J;Yang K;Boone JM;Han X;Sidky EY;Pan X

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人们有兴趣开发专门用于乳腺癌成像的计算机断层扫描(CT)。由于乳腺组织对辐射敏感,因此乳腺CT扫描中的总辐射暴露保持较低,通常与典型的双视图乳腺X射线摄影检查相当,从而导致具有挑战性的低剂量数据重建问题。近年来,有证据表明,迭代重建可以从低剂量数据中获得质量更好的图像。本文基于约束图像全变差(TV)最小化程序及其数值求解器,自适应最陡下降投影到凸集(ASD-POCS),我们调查和评估迭代图像重建从低剂量乳腺CT数据的患者,重点是识别和确定关键的重建参数,设计替代效用度量表征重建质量,并定制程序和ASD-POCS的具体重建任务考虑。在主观可视化和替代效用指标方面,ASD-POCS重建似乎优于相应的临床FDK重建。
Interest exists in developing computed tomography (CT) dedicated for breast-cancer imaging. Because breast tissues are radiation-sensitive, the total radiation exposure in a breast-CT scan is kept low, often comparable to a typical two-view mammography exam, thus resulting in a challenging low-dose-data-reconstruction problem. In recent years, evidence exists suggesting that iterative reconstruction may yield images of improved quality from low-dose data. In this work, based upon the constrained image-total-variation (TV) minimization program and its numerical solver, i.e., the adaptive steepest descent-projection onto the convex set (ASD-POCS), we investigate and evaluate iterative image reconstructions from low-dose breast-CT data of patients, with focuses on identifying and determining key reconstruction parameters, devising surrogate utility metrics for characterizing reconstruction quality, and tailoring the program and ASD-POCS to the specific reconstruction task under consideration. The ASD-POCS reconstructions appear to outperform the corresponding clinical FDK reconstructions, in terms of subjective visualization and surrogate utility metrics.
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