The multimorbidity profile of South African women newly diagnosed with breast cancer.
The multimorbidity profile of South African women newly diagnosed with breast cancer.
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DOI：
10.1002/ijc.32727
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发表时间：
2020-07-15
影响因子：
6.4
通讯作者：
Micklesfield LK
中科院分区：
文献类型：
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作者：
Ayeni OA;Norris SA;Joffe M;Cubasch H;Nietz S;Buccimazza I;Singh U;Čačala S;Stopforth L;Chen WC;McCormack VA;O'Neil DS;Jacobson JS;Neugut AI;Ruff P;Micklesfield LK
乳腺癌妇女的多发病可能会延迟表现，影响治疗决定和结果。我们描述了乳腺癌妇女的多发病特征，其决定因素，与诊断阶段和接受治疗的关系。我们收集了五种慢性疾病（高血压，糖尿病，脑血管疾病，哮喘/慢性阻塞性肺病，结核病）的自我报告数据，使用体重指数（BMI）确定肥胖，并测试了艾滋病毒状态，在2016年1月至2018年4月期间在南非的5家公立医院新诊断为乳腺癌的女性中。我们确定了上述7种疾病中≥2种的决定因素（定义为多发性硬化）、多发性硬化本身与诊断时的分期（晚期（III-IV）vs.早期（0-II））以及多发性硬化与接受的治疗方式。在2281名妇女中，1001名（44%）患有多发性硬化症。肥胖（52.8%）、高血压（41.3%）、艾滋病毒（22.0%）和糖尿病（13.7%）是最常见的慢性疾病。年龄越大（OR=1.02; 95%CI 1.01-1.03）和家庭社会经济地位（HSES）越高（OR=1.06; 95%CI 1.00-1.13），多发性骨髓瘤越常见。在诊断时，多发性硬化症与晚期乳腺癌无关，但在校正模型中，自我报告的高血压患者被诊断为晚期乳腺癌的可能性较小（OR 0.80; 95%CI 0.64-0.98）。多药耐药与早期疾病患者接受的首次治疗相关，p=0.003。在乳腺癌患者中，多发性乳腺癌的患病率很高。我们的研究结果表明，多发病对早期疾病患者接受的治疗有显着影响。有必要了解多药耐药对乳腺癌预后的影响。
Multimorbidity in women with breast cancer may delay presentation, affect treatment decisions and outcomes. We described the multimorbidity profile of women with breast cancer, its determinants, associations with stage at diagnosis and treatments received. We collected self-reported data on five chronic conditions (hypertension, diabetes, cerebrovascular diseases, asthma/chronic obstructive pulmonary disease, tuberculosis), determined obesity using body mass index (BMI), and tested HIV status, in women newly diagnosed with breast cancer between January 2016 and April 2018 in 5 public hospitals in South Africa. We identified determinants of ≥2 of the 7 above mentioned conditions (defined as multimorbidity), multimorbidity itself with stage at diagnosis (advanced (III-IV) vs. early (0-II)) and multimorbidity with treatment modalities received. Among 2281 women, 1001 (44%) presented with multimorbidity. Obesity (52.8%), hypertension (41.3%), HIV (22.0%) and diabetes (13.7%) were the chronic conditions that occurred most frequently. Multimorbidity was more common with older age (OR=1.02; 95% CI 1.01–1.03) and higher household socioeconomic status (HSES) (OR=1.06; 95% CI 1.00–1.13). Multimorbidity was not associated with advanced stage breast cancer at diagnosis, but for self-reported hypertension there was less likelihood of being diagnosed with advanced stage disease in the adjusted model (OR 0.80; 95% CI 0.64–0.98). Multimorbidity was associated with first treatment received in those with early stage disease, p=0.003. The prevalence of multimorbidity is high among patients with breast cancer. Our findings suggest that multimorbidity had a significant impact on treatment received in those with early stage disease. There is need to understand the impact of multimorbidity on breast cancer outcomes.
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影响因子：
--
作者：
Fu, Mei R.;Axelrod, Deborah;Melkus, Gail D'Eramo
通讯作者：
Melkus, Gail D'Eramo
影响因子：
4.8
作者：
Ataguba JE
通讯作者：
Ataguba JE
影响因子：
1.8
作者：
Govind Babu K;Anand A;Lakshmaiah KC;Lokanatha D;Jacob LA;Suresh Babu MC;Lokesh KN;Rudresha HA;Rajeev LK;Saldanha SC;Giri GV;R C;Koppaka D;Panwar D;Kumar RV
通讯作者：
Kumar RV
DOI：
10.4102/phcfm.v8i1.1248
发表时间：
2016-11-17
影响因子：
2
作者：
Mahomed, Ozayr H;Asmall, Shaidah;Voce, Anna
通讯作者：
Voce, Anna
影响因子：
4.8
作者：
Alaba, Olufunke;Chola, Lumbwe
通讯作者：
Chola, Lumbwe