Nuclear expression of snail is an independent negative prognostic factor in human breast cancer.
Nuclear expression of snail is an independent negative prognostic factor in human breast cancer.
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DOI：
10.1155/2013/902042
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Soysal SD
中科院分区：
文献类型：
--
作者：
Muenst S;Däster S;Obermann EC;Droeser RA;Weber WP;von Holzen U;Gao F;Viehl C;Oertli D;Soysal SD
背景Snail是肿瘤细胞上皮间质转化的关键调节因子。几项研究表明，核Snail表达是人类癌症的一个负面预后因素，通常与更具侵袭性的肿瘤行为和更差的生存率相关。目标和方法。为了进一步探索Snail表达在乳腺癌中的作用，我们在组织芯片上进行了一项研究，包括1043例乳腺癌病例。结果共有265例（25.4%）乳腺癌为Snail阳性。Snail表达与较大的肿瘤大小、较高的肿瘤分期和分级、阳性淋巴结状态和激素受体阴性状态显著相关，并且在乳腺癌的内在亚型中表达不同，在基底样亚型中表达最高，在管腔A亚型中表达最低。在多变量分析中，Snail被证明是OS的一个独立的负性预后因素。在内在亚型中，Snail表达是管腔型B HER2−、管腔型B HER2+和基底样亚型中OS的一个负性预后因素。结论.这是第一项研究表明，核Snail表达是乳腺癌预后的独立阴性预测因子，因此表明它可能代表潜在的治疗靶点。
Background. Snail is a key regulator of epithelial-mesenchymal transition of tumor cells. Several studies have shown nuclear Snail expression to be a negative prognostic factor in human cancer, where it is generally associated with more aggressive tumor behavior and worse survival. Objectives and Methods. To further explore the role of Snail expression in breast cancer, we conducted a study on a tissue microarray, encompassing 1043 breast cancer cases. Results. A total of 265 (25.4%) breast cancers were positive for Snail. Snail expression was significantly associated with greater tumor size, higher tumor stage and grade, positive lymph node status, and hormone receptor negative status and was differently expressed in the intrinsic subtypes of breast cancer, being the highest in the basal-like subtype and the lowest in the luminal A subtype. In multivariate analysis, Snail proved to be an independent negative prognostic factor for OS. In the intrinsic subtypes, Snail expression was a negative prognostic factor for OS in the luminal B HER2−, the luminal B HER2+, and the basal-like subtype. Conclusions. This is the first study demonstrating that nuclear Snail expression is an independent negative predictor of prognosis in breast cancer, thus suggesting that it may represent a potential therapeutic target.
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影响因子：
--
作者：
Fujita, N;Kajita, M;Wade, PA
通讯作者：
Wade, PA
影响因子：
3.3
作者：
Geradts J;de Herreros AG;Su Z;Burchette J;Broadwater G;Bachelder RE
通讯作者：
Bachelder RE
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
DOI：
10.1073/pnas.0906423106
发表时间：
2009-08-18
影响因子：
11.1
作者：
Harney, Allison S.;Lee, Jiyoun;Meade, Thomas J.
通讯作者：
Meade, Thomas J.
影响因子：
50.3
作者：
Moody, SE;Perez, D;Chodosh, LA
通讯作者：
Chodosh, LA