Changes in natural killer cell subsets in pediatric liver transplant recipients.
Changes in natural killer cell subsets in pediatric liver transplant recipients.
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DOI：
10.1111/j.1399-3046.2012.01653.x
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发表时间：
2012-03
影响因子：
1.3
通讯作者：
Krams SM
中科院分区：
文献类型：
--
作者：
Pham B;Piard-Ruster K;Silva R;Gallo A;Esquivel CO;Martinez OM;Krams SM
Natural killer (NK) cells are important in the immune response against tumors and virally infected cells. A balance of inhibitory and activating receptors controls the effector functions of NK cells. We examined the fate of circulating NK cells and the expression of the NK cell activating receptors in pediatric liver transplant recipients. Blood specimens were collected from 38 pediatric liver transplant recipients before transplant, and at 1 week, 1, 3, 6, and 9 months, and 1 year post-transplant. PBMC were isolated and analyzed for the levels of NK cell activation receptors NKp30, NKp46, and NKG2D in the CD56dimCD16+ and CD56brightCD16+/− subsets of NK cells. We demonstrated that there is a significant decrease in the number of circulating NK cells post-transplant (pre-transplant 7.69 ± 1.54 vs. one week post-transplant 1.73 ± 0.44) in pediatric liver transplant recipients. Interestingly, NKp30 expression is significantly increased while NKp46 and NKG2D levels remain stable on the NK cells that persist at one-week post-transplant. These data indicate that the numbers and subsets of circulating NK cells are altered in children after liver transplantation.
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