Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance.
Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance.
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DOI：
10.1016/j.jhep.2010.11.030
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发表时间：
2011-08
影响因子：
25.7
通讯作者：
Lauer GM
中科院分区：
文献类型：
--
作者：
Alter G;Jost S;Rihn S;Reyor LL;Nolan BE;Ghebremichael M;Bosch R;Altfeld M;Lauer GM
虽然大多数感染丙型肝炎的患者进展为慢性肝炎，但一小部分人能够清除病毒。感染在感染的最初几周到几个月内就会消失，这表明先天免疫功能可能对早期控制至关重要。流行病学数据支持特定的NK细胞受体携带者在这一对照中的作用，然而NK细胞在感染早期对丙型肝炎病毒做出反应的机制尚不清楚。研究了43名在不同临床结局的丙型肝炎病毒感染不同阶段的个体中NK细胞的表型和功能的变化。急性、慢性和消退的丙型肝炎病毒感染的特征是CD56neg NK细胞的扩张。此外，在丙型肝炎病毒感染者中，观察到与HLAC结合的KIR+NK细胞水平升高，而所有阶段的丙型肝炎病毒感染都与NKG2D+、NKp30+和NKp46+NK细胞百分率降低有关，而NK细胞对带有这些受体配体的靶细胞的应答能力略有增加。而NKG2A+和CD94+NK细胞在急性和慢性丙型肝炎感染时升高，而在消退感染时则无明显变化。最重要的是，在急性感染中，随后能够清除丙型肝炎病毒感染的患者中，NKp30+、NKp46+、CD161+和NKG2D+NK细胞的频率低于慢性感染患者。这些数据表明特定的NK细胞群在早期控制和清除丙型肝炎病毒感染中起作用。
While the majority of HCV-infected patients progress to chronic hepatitis, a small fraction of individuals are able to clear the virus. Resolution of infection occurs within the first few weeks to months of infection, suggesting that innate immune functions may be critical for early control. Epidemiologic data support a role for particular NK cell receptor bearing populations in this control, yet the mechanism by which NK cells respond to HCV early in infection is unknown. Changes in the phenotype and function of NK cells were investigated in a cohort of 43 individuals identified during various stages of HCV infection with different clinical outcomes. Acute, chronic, and resolved HCV infections were characterized by an expansion of CD56neg NK cells. Furthermore, increased levels of HLA-C-binding KIR+ NK cells were observed in HCV resolvers, while all stages of HCV infection were associated with reduced percentages of NKG2D+, NKp30+, and NKp46+ NK cells, and a slight increase in the ability of NK cells to respond to target cells bearing the ligands for these receptors. In contrast, NKG2A+ and CD94+ NK cells were elevated in acute and chronic HCV infection, but not in resolved infection. Most importantly, in acute infection, lower frequencies of NKp30+, NKp46+, CD161+, and NKG2D+ NK cells were observed in patients who were subsequently able to clear HCV infection than in those becoming chronically infected. These data implicate particular populations of NK cells in the early control and clearance of HCV infection.
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影响因子：
15.3
作者：
Crotta, Stefania;Stilla, Annalisa;Wack, Andreas;D'Andrea, Annalisa;Nuti, Sandra;D'Oro, Ugo;Mosca, Marta;Filliponi, Franco;Brunetto, R Maurizia;Bonino, Ferruccio;Abrignani, Sergio;Valiante, Nicholas M
通讯作者：
Valiante, Nicholas M
DOI：
10.1073/pnas.0409872102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Mavilio, D;Lombardo, G;Fauci, AS
通讯作者：
Fauci, AS
影响因子：
13.5
作者：
Golden-Mason, Lucy;Cox, Andrea L.;Randall, Jessica A.;Cheng, Linling;Rosen, Hugo R.
通讯作者：
Rosen, Hugo R.
影响因子：
56.9
作者：
Grakoui, A;Shoukry, NH;Walker, CM
通讯作者：
Walker, CM
影响因子：
5.4
作者：
De Maria, Andrea;Fogli, Manuela;Moretta, Lorenzo
通讯作者：
Moretta, Lorenzo