Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection.
Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection.
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DOI：
10.1002/eji.200939779
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发表时间：
2010-06
影响因子：
5.4
通讯作者：
Krams, Sheri M.
中科院分区：
文献类型：
--
作者：
Zhuo, Ming;Fujiki, Masato;Wang, Mouer;Piard-Ruster, Karine;Wai, Lu-En;Wei, Liang;Martinez, Olivia M.;Krams, Sheri M.
NKG2D is a receptor expressed by natural killer (NK) cells and subsets of T lymphocytes. On NK cells, NKG2D functions as a stimulatory receptor that induces effector functions. We cloned and expressed two rat NKG2D ligands, both members of the RAE1 family, RAE1L and RRLT, and demonstrate that these ligands can induce IFNγ secretion and cytotoxicity by rat NK cells. To examine changes in expression of NKG2D and the NKG2D ligands RAE1L and RRLT after transplantation, we used a DALewis rat model of liver transplantation. NKG2D expression was significantly increased in allogeneic liver grafts by day seven post-transplant. Ligands of NKG2D, absent in normal liver, were readily detected in both syngeneic and allogeneic liver grafts by day one post-transplant. By day seven post-transplant, hepatocyte RAE1L and RRLT expression was significantly and specifically increased in liver allografts. In contrast to acute rejection that develops in the DALewis model, transplantation of Lewis livers into DA recipients (LewisDA) results in spontaneous tolerance. Interestingly, expression of RAE1L and RRLT is low in LewisDA liver allografts, but significantly increased in rejecting DALewis liver allografts. In conclusion, our results suggest that expression of NKG2D ligands may be important in allograft rejection.
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DOI：
10.1084/jem.20090225
发表时间：
2009-02-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cerwenka A
通讯作者：
Cerwenka A
DOI：
10.1084/jem.20081335
发表时间：
2009-02-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Nice TJ;Coscoy L;Raulet DH
通讯作者：
Raulet DH
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
影响因子：
30.5
作者：
Ogasawara, K;Benjamin, J;Lanier, LL
通讯作者：
Lanier, LL
DOI：
10.1073/pnas.93.22.12445
发表时间：
1996-10-29
影响因子：
11.1
作者：
Groh, V;Bahram, S;Spies, T
通讯作者：
Spies, T