Biomarkers of patient intrinsic risk for upper and lower airway injury after exposure to the World Trade Center atrocity.
Biomarkers of patient intrinsic risk for upper and lower airway injury after exposure to the World Trade Center atrocity.
复制标题
暴露于世贸中心暴行后患者上、下呼吸道损伤内在风险的生物标志物。
DOI：
10.1002/ajim.22643
复制
发表时间：
2016
影响因子：
3.5
通讯作者：
Weiden,MichaelD
中科院分区：
文献类型：
--
作者：
Zeig-Owens,Rachel;Nolan,Anna;Putman,Barbara;Singh,Ankura;Prezant,DavidJ;Weiden,MichaelD
背景纽约市消防局（FDNY）工作人员暴露于世界贸易中心（WTC）灾难现场，上呼吸道和下呼吸道疾病的发病率较高。大多数患者出现肺功能急性下降，有些患者在14年的随访中持续下降。同样，一些鼻窦炎患者有需要鼻窦手术的症状。我们描述了不需要储存血清的上呼吸道和下呼吸道损伤风险的生物标志物。MethodsWe回顾了WTC生物标志物文献。结论这项研究将有助于确定在这些之后发展的肺和鼻窦疾病的高风险个体，或未来的刺激性暴露，进行强化监测和治疗。它还可以确定有效治疗干预的目标。Am. J. Ind. Med. 59：788-794，2016。© 2016 Wiley Periodicals，Inc.
BackgroundHigh rates of upper and lower airways disease have occurred in Fire Department of the City of New York (FDNY) workers exposed to the World Trade Center (WTC) disaster site. Most experienced acute declines in pulmonary function, and some continued to experience decline over 14 years of follow‐up. Similarly, some with rhinosinusitis had symptoms requiring sinus surgery.AimTo increase generalizability of biomarker investigation, we describe biomarkers of risk for upper and lower airway injury that do not require stored serum.MethodsWe review WTC biomarker literature.ResultsCytokines expressed in stored serum from the first 6 months post‐9/11 can identify individuals at higher risk for future abnormal pulmonary function.ConclusionThis research will help identify individuals at high risk of lung and sinus disease that develop after these, or future, irritant exposures for intensive monitoring and treatment. It may also identify targets for effective therapeutic interventions. Am. J. Ind. Med. 59:788–794, 2016. © 2016 Wiley Periodicals, Inc.
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影响因子：
14.2
作者：
Stone, Kelly D.;Prussin, Calman;Metcalfe, Dean D.
通讯作者：
Metcalfe, Dean D.
世贸中心灾难发生 7-9 年后，医生诊断出呼吸系统疾病和心理健康症状。
影响因子：
3.5
作者：
Webber,MayrisP;Glaser,MichelleS;Weakley,Jessica;Soo,Jackie;Ye,Fen;Zeig-Owens,Rachel;Weiden,MichaelD;Nolan,Anna;Aldrich,ThomasK;Kelly,Kerry;Prezant,David
通讯作者：
Prezant,David
影响因子：
9.6
作者：
Aldrich, Thomas K.;Vossbrinck, Madeline;Prezant, David J.
通讯作者：
Prezant, David J.
影响因子：
4.3
作者：
Cho, Soo Jung;Echevarria, Ghislaine C.;Kwon, Sophia;Naveed, Bushra;Schenck, Edward J.;Tsukiji, Jun;Rom, William N.;Prezant, David J.;Nolan, Anna;Weiden, Michael D.
通讯作者：
Weiden, Michael D.
DOI：
10.1056/nejmoa1101388
发表时间：
2011-07-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
King MS;Eisenberg R;Newman JH;Tolle JJ;Harrell FE Jr;Nian H;Ninan M;Lambright ES;Sheller JR;Johnson JE;Miller RF
通讯作者：
Miller RF