One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure.
One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure.
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DOI：
10.1016/j.rmed.2013.11.002
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发表时间：
2014-01
影响因子：
4.3
通讯作者：
Weiden, Michael D.
中科院分区：
文献类型：
--
作者：
Cho, Soo Jung;Echevarria, Ghislaine C.;Kwon, Sophia;Naveed, Bushra;Schenck, Edward J.;Tsukiji, Jun;Rom, William N.;Prezant, David J.;Nolan, Anna;Weiden, Michael D.
暴露于世界贸易中心（WTC）灰尘的消防员已发展为慢性鼻窦炎（CRS）和1秒用力呼气量（FEV 1）异常。重叠但不同的免疫反应可能是导致上、下气道损伤的临床表现的原因。我们研究了一组炎性细胞因子，无论是否与WTC-LI相关，都可以预测未来的慢性鼻窦炎疾病及其严重程度。对2001年9月11日6个月内从179名在2008年3月之前进行亚专业评估的WTC暴露消防员中获得的血清进行了39种细胞因子的测定。主要结局为药物管理的CRS（N=62）和需要鼻窦手术的更严重CRS病例（N=14）。我们使用有序逻辑回归分析来检验生物标志物-CRS严重程度关联。血清IL-6、IL-8、GRO和中性粒细胞浓度升高可降低CRS进展的风险。相反，增加TNF-α会增加疾病进展的风险。在根据暴露强度调整的多变量模型中，IL-6、TNF-α和中性粒细胞浓度的增加仍然是进展的重要预测因素。IL-6水平和中性粒细胞计数升高也降低了FEV 1异常的风险，但与CRS相反，TNF-α升高并不增加FEV 1异常的风险。我们的研究证明了独立和重叠的生物标志物与上呼吸道和下呼吸道损伤的相关性，并表明先天免疫应答可能在WTC暴露的患者中对CRS和异常肺功能起保护作用。
Firefighters exposed to World Trade Center (WTC) dust have developed chronic rhinosinusitis (CRS) and abnormal forced expiratory volume in 1 second (FEV1). Overlapping but distinct immune responses may be responsible for the clinical manifestations of upper and lower airway injury. We investigated whether a panel of inflammatory cytokines, either associated or not associated with WTC-LI, can predict future chronic rhinosinusitis disease and its severity. Serum obtained within six months of 9/11/2001 from 179 WTC exposed firefighters presenting for subspecialty evaluation prior to 3/2008 was assayed for 39 cytokines. The main outcomes were medically managed CRS (N=62) and more severe CRS cases requiring sinus surgery (N=14). We tested biomarker-CRS severity association using ordinal logistic regression analysis. Increasing serum IL-6, IL-8, GRO and neutrophil concentration reduced the risk of CRS progression. Conversely, increasing TNF-α increased the risk of progression. In a multivariable model adjusted for exposure intensity, increasing IL-6, TNF-α and neutrophil concentration remained significant predictors of progression. Elevated IL-6 levels and neutrophil counts also reduced the risk of abnormal FEV1 but in contrast to CRS, increased TNF-α did not increase the risk of abnormal FEV1. Our study demonstrates both independent and overlapping biomarker associations with upper and lower respiratory injury, and suggests that the innate immune response may play a protective role against CRS and abnormal lung function in those with WTC exposure.
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影响因子：
4.5
作者：
Melzer D;Perry JR;Hernandez D;Corsi AM;Stevens K;Rafferty I;Lauretani F;Murray A;Gibbs JR;Paolisso G;Rafiq S;Simon-Sanchez J;Lango H;Scholz S;Weedon MN;Arepalli S;Rice N;Washecka N;Hurst A;Britton A;Henley W;van de Leemput J;Li R;Newman AB;Tranah G;Harris T;Panicker V;Dayan C;Bennett A;McCarthy MI;Ruokonen A;Jarvelin MR;Guralnik J;Bandinelli S;Frayling TM;Singleton A;Ferrucci L
通讯作者：
Ferrucci L
DOI：
10.1164/rccm.201109-1672oc
发表时间：
2012-02-15
影响因子：
24.7
作者：
Naveed, Bushra;Weiden, Michael D.;Nolan, Anna
通讯作者：
Nolan, Anna
影响因子：
10.4
作者：
Lioy PJ;Weisel CP;Millette JR;Eisenreich S;Vallero D;Offenberg J;Buckley B;Turpin B;Zhong M;Cohen MD;Prophete C;Yang I;Stiles R;Chee G;Johnson W;Porcja R;Alimokhtari S;Hale RC;Weschler C;Chen LC
通讯作者：
Chen LC
影响因子：
5.3
作者：
Bosse, Yohan;Bacot, Francois;Desrosiers, Martin
通讯作者：
Desrosiers, Martin
影响因子：
14.2
作者：
Braunstahl, GJ;Overbeek, SE;Fokkens, WJ
通讯作者：
Fokkens, WJ