Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity.
Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity.
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DOI：
10.1038/s41467-023-37613-7
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发表时间：
2023-04-03
影响因子：
16.6
通讯作者：
Engel, Tatiana A.
中科院分区：
文献类型：
--
作者：
Zeraati, Roxana;Shi, Yan-Liang;Steinmetz, Nicholas A.;Gieselmann, Marc A.;Thiele, Alexander;Moore, Tirin;Levina, Anna;Engel, Tatiana A.
内在时间尺度表征神经活动中内源性波动的动力学。新皮层的内在时间尺度的变化反映了皮层区域的功能特化，但对认知任务中内在时间尺度的变化知之甚少。我们测量了执行空间注意任务的雄性猴子的V4区列内的局部尖峰活动的内在时间尺度。持续的尖峰活动在至少两个不同的时间尺度上展开，快的和慢的。当猴子注意到感受野的位置时，缓慢的时间尺度增加，并与反应时间相关。通过评估几个网络模型的预测，我们发现，V4活动的时空相关性最好的解释模型，其中多个时间尺度产生的经常性的相互作用，形成空间排列的连接，和注意力调制的时间尺度的结果，从增加的功效经常性的相互作用。我们的研究结果表明，多个时间尺度可能会出现在视觉皮层的空间连接和灵活的认知状态，由于动态有效的神经元之间的相互作用而变化。对于表征神经活动内源性波动动态的内在时间尺度在认知任务中如何变化，我们知之甚少。在这里，作者表明，灵长类动物视觉皮层神经活动的内在时间尺度在空间注意过程中发生变化。实验数据最好的解释网络模型中，时间尺度产生的空间排列的连接。
Intrinsic timescales characterize dynamics of endogenous fluctuations in neural activity. Variation of intrinsic timescales across the neocortex reflects functional specialization of cortical areas, but less is known about how intrinsic timescales change during cognitive tasks. We measured intrinsic timescales of local spiking activity within columns of area V4 in male monkeys performing spatial attention tasks. The ongoing spiking activity unfolded across at least two distinct timescales, fast and slow. The slow timescale increased when monkeys attended to the receptive fields location and correlated with reaction times. By evaluating predictions of several network models, we found that spatiotemporal correlations in V4 activity were best explained by the model in which multiple timescales arise from recurrent interactions shaped by spatially arranged connectivity, and attentional modulation of timescales results from an increase in the efficacy of recurrent interactions. Our results suggest that multiple timescales may arise from the spatial connectivity in the visual cortex and flexibly change with the cognitive state due to dynamic effective interactions between neurons. Not much is known about how intrinsic timescales, which characterize the dynamics of endogenous fluctuations in neural activity, change during cognitive tasks. Here, the authors show that intrinsic timescales of neural activity in the primate visual cortex change during spatial attention. Experimental data were best explained by a network model in which timescales arise from spatially arranged connectivity.
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影响因子：
2.4
作者：
GINZBURG, I;SOMPOLINSKY, H
通讯作者：
SOMPOLINSKY, H
DOI：
10.1073/pnas.1607601113
发表时间：
2016-10-18
影响因子：
11.1
作者：
Berman, Gordon J.;Bialek, William;Shaevitz, Joshua W.
通讯作者：
Shaevitz, Joshua W.
影响因子：
7.7
作者：
Chaudhuri R;Bernacchia A;Wang XJ
通讯作者：
Wang XJ
影响因子：
3.4
作者：
Gieselmann, M. A.;Thiele, A.
通讯作者：
Thiele, A.
影响因子：
3.5
作者：
Cavanagh SE;Hunt LT;Kennerley SW
通讯作者：
Kennerley SW