Experimental and theoretical characterization of the voltage distribution generated by deep brain stimulation.
Experimental and theoretical characterization of the voltage distribution generated by deep brain stimulation.
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DOI：
10.1016/j.expneurol.2008.11.024
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发表时间：
2009-03
影响因子：
5.3
通讯作者：
McIntyre, Cameron C.
中科院分区：
文献类型：
--
作者：
Miocinovic, Svjetlana;Lempka, Scott F.;Russo, Gary S.;Maks, Christopher B.;Butson, Christopher R.;Sakaie, Ken E.;Vitek, Jerrold L.;McIntyre, Cameron C.
关键词：
脑深部电刺激（DBS）是一种治疗帕金森病的既定疗法，对许多其他疾病也显示出巨大的希望。虽然DBS的基本目的是用电场调节神经活动，但人们对DBS电极在大脑中产生的实际电压分布知之甚少，因此很难准确预测哪些大脑区域直接受到刺激。本研究的目的是表征DBS电极产生的电压分布的时空特征。我们通过实验记录了在生理盐水中或植入非人类灵长类动物大脑中的激活DBS电极周围的电压。在电压控制和电流控制刺激期间进行记录。将实验结果与参数化的DBS体导体电场模型进行了比较，以匹配不同的实验结果。有三个因素直接影响实验和理论电压测量：1)DBS电极阻抗，主要由电极-电解质界面处的电压降和组织介质的电导率决定，2)刺激波形的电容调制，以及3)组织介质的非均匀性和各向异性。虽然电压分布不能直接预测DBS的神经反应，但本研究的结果确实为理解DBS的电参数和表征其对神经系统的影响提供了基础构建块。
Deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson’s disease and shows great promise for numerous other disorders. While the fundamental purpose of DBS is to modulate neural activity with electric fields, little is known about the actual voltage distribution generated in the brain by DBS electrodes and as a result it is difficult to accurately predict which brain areas are directly affected by the stimulation. The goal of this study was to characterize the spatial and temporal characteristics of the voltage distribution generated by DBS electrodes. We experimentally recorded voltages around active DBS electrodes in either a saline bath or implanted in the brain of a non-human primate. Recordings were made during voltage-controlled and current-controlled stimulation. The experimental findings were compared to volume conductor electric field models of DBS parameterized to match the different experiments. Three factors directly affected the experimental and theoretical voltage measurements: 1) DBS electrode impedance, primarily dictated by a voltage drop at the electrode-electrolyte interface and the conductivity of the tissue medium, 2) capacitive modulation of the stimulus waveform, and 3) inhomogeneity and anisotropy of the tissue medium. While the voltage distribution does not directly predict the neural response to DBS, the results of this study do provide foundational building blocks for understanding the electrical parameters of DBS and characterizing its effects on the nervous system.
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DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
2.8
作者：
Hemm, S;Vayssiere, N;Coubes, P
通讯作者：
Coubes, P
影响因子：
4
作者：
Astrom, Mattias;Johansson, Johannes D.;Wardell, Karin
通讯作者：
Wardell, Karin
影响因子：
5.7
作者：
Butson, Christopher R.;Cooper, Scott E.;McIntyre, Cameron C.
通讯作者：
McIntyre, Cameron C.
影响因子：
4.7
作者：
Butson, CR;Maks, CB;McIntyre, CC
通讯作者：
McIntyre, CC