Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model.
Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model.
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DOI：
10.1016/j.amjsurg.2016.09.013
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发表时间：
2016-12
影响因子：
3
通讯作者：
Blair, Sarah
中科院分区：
文献类型：
--
作者：
Ward, Erin P.;Wang, James;Mendez, Natalie;Yang, Jian;Barback, Chris;Wang-Rodriguez, Jessica;Trogler, William;Kummel, Andrew C.;Blair, Sarah
我们的目的是评估超声（US）可见生物可降解纳米壳（NS）作为体内不可触及肿瘤导丝定位（WL）替代方法的潜力。在22只新西兰兔的双侧大腿注射VX 2肿瘤，5-10天后，在多普勒超声下用金属丝标记一个肿瘤作为对照，并在对侧肿瘤中注射1 mL的500 nm充气二氧化硅NS。24小时后切除肿瘤。卡方用于显著性，p= 0.05。1只家兔在术后第1天因设备故障被排除，未观察到NS的不良反应。NS用于定位和切除100%的标记组织，4/21根导丝移位（p<0.05）。我们已经证明，术前注射的US可见二氧化硅NS可以成功地用于标记体内不可触及的肿瘤，比WL更一致。
We aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire guided localization (WL) for non-palpable tumors in vivo. VX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5-10 days one tumor was marked with a wire as a control and the contralateral tumor was injected with 1mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chi square was utilized for significance, p=.05. One rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were utilized to localize and resect 100% of marked tissue, 4/21 wires were displaced (p<.05) . We have shown that preoperatively injected US visible silica NS can be successfully utilized to mark non-palpable tumors in vivo more consistently than WL.
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影响因子：
254.7
作者：
DeSantis, Carol;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
3
作者：
Mullenix, PS;Cuadrado, DG;Carter, PL
通讯作者：
Carter, PL
影响因子：
5
作者：
Sharek, Danielle;Zuley, Margarita L.;Ganott, Marie A.
通讯作者：
Ganott, Marie A.
影响因子：
19
作者：
Liberman A;Wang J;Lu N;Viveros RD;Allen CA;Mattrey RF;Blair SL;Trogler WC;Kim MJ;Kummel AC
通讯作者：
Kummel AC
影响因子：
158.5
作者：
Fisher, B;Anderson, S;Wolmark, N
通讯作者：
Wolmark, N