Arsenic sulfide as a potential anti‑cancer drug.
Arsenic sulfide as a potential anti‑cancer drug.
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硫化砷作为潜在的抗癌药物
DOI：
10.3892/mmr.2014.2838
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发表时间：
2015-02
影响因子：
3.4
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Ding W;Zhang L;Kim S;Tian W;Tong Y;Liu J;Ma Y;Chen S
硫化砷（As 4S 4）是雄黄的主要成分，在中药中有着广泛的应用。已有研究表明As 4S 4对血液系统恶性疾病的治疗有一定的作用，但其对实体瘤的作用尚未完全阐明。本研究旨在探讨As 4S 4在体内外对实体瘤的抗癌作用及其机制。以L02胚肝细胞为对照，用As 4S 4处理4种人实体瘤细胞系，包括MKN 45胃癌细胞系、A375恶性黑色素瘤细胞系、8898胰腺癌细胞系和HepG 2肝癌细胞系。使用植入刘易斯肺癌细胞的小鼠体内评估As 4S 4的功效。本研究的结果表明，As 4S 4以剂量和时间依赖的方式显著抑制实体瘤细胞的增殖，但对L02细胞的作用不太明显。此外，观察到As 4S 4诱导细胞凋亡（包括形态学变化和增强的亚G1群），这伴随着caspase-3和-9的激活。此外，用As 4S 4处理显著抑制小鼠中植入的肿瘤的生长。这些结果表明As 4S 4通过诱导细胞凋亡具有较强的体内外抗肿瘤活性。
Arsenic sulfide (As4S4) is the main component of realgar, which is widely used in traditional Chinese medicine. Previous studies have shown the beneficial effects of As4S4 in the treatment of hematological malignant diseases, however, its effects on solid tumors have yet to be fully elucidated. The current study aimed to explore the anti-cancer effect and the mechanism of As4S4 on solid tumors in vitro and in vivo. Cells from four human solid tumor cell lines, including the MKN45 gastric cancer cell line, the A375 malignant melanoma cell line, the 8898 pancreatic carcinoma cell line and the HepG2 hepatocellular carcinoma cell line, were treated with As4S4 in vitro, using the L02 embryonic liver cells as a control. The efficacy of As4S4 was assessed in vivo using mice implanted with Lewis lung carcinoma cells. The results of the current study demonstrated that As4S4 significantly inhibited the proliferation of solid tumor cells in a dose- and time-dependent manner, but produced a less pronounced effect on L02 cells. Additionally, As4S4 was observed to induce apoptosis (including morphological changes and an enhanced sub-G1 population), which was accompanied by the activation of caspase-3 and −9. Furthermore, treatment with As4S4 significantly inhibited the growth of implanted tumors in mice. These results suggest that As4S4 possesses potent in vitro and in vivo antitumor activity via the induction of cell apoptosis.
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影响因子：
6.5
作者：
Rojewski, MT;Baldus, C;Schrezenmeier, H
通讯作者：
Schrezenmeier, H
影响因子：
7.2
作者：
McIlwain, David R.;Berger, Thorsten;Mak, Tak W.
通讯作者：
Mak, Tak W.
影响因子：
56.9
作者：
SMITH, KA
通讯作者：
SMITH, KA
影响因子：
5.8
作者：
Waxman, S;Anderson, KC
通讯作者：
Anderson, KC
影响因子：
3.5
作者：
Ramanathan, K;Anusuyadevi, M;Panneerselvam, C
通讯作者：
Panneerselvam, C