Epilepsy duration impacts on brain glucose metabolism in temporal lobe epilepsy: results of voxel-based mapping.
Epilepsy duration impacts on brain glucose metabolism in temporal lobe epilepsy: results of voxel-based mapping.
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癫痫持续时间对颞叶癫痫中脑葡萄糖代谢的影响：基于体素的映射结果。
DOI：
10.1016/j.yebeh.2009.12.007
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发表时间：
2010-03
影响因子：
2.6
通讯作者：
Gilliam, Frank
中科院分区：
文献类型：
--
作者：
Akman, Cigdem I.;Ichise, Masonori;Olsavsky, Aviva;Tikofsky, Ronald S.;Van Heerturn, Ronald L.;Gilliam, Frank
关键词：
[18 F]氟脱氧葡萄糖正电子发射断层扫描（[18 F]FDG-PET）是检测癫痫相关局灶性脑功能障碍的一种有价值的方法。有证据表明，随着癫痫持续时间的增加，致癫痫皮质中[18 F]FDG摄取逐渐减少。在这项研究中，我们的目的是使用统计参数映射（SPM），以测试这种关系的有效性在颞叶癫痫（TLE）患者的回顾性研究。对46例药物耐药单侧TLE（25例RTLE和21例LTLE）成人患者的[18 F]FDG-PET扫描进行SPM分析。46例患者被诊断为非病变性TLE，其中16例有海马硬化（HS）。癫痫的平均持续时间为17.4 ± 12.3年（3 - 46年），10例患者<5年，30例患者≥10年。[18F]FDG-PET扫描的视觉分析显示31例（67%）患者的致癫痫颞叶皮质代谢低下。在对所有[18 F]FDG-PET图像进行SPM分析后，除了同侧梭状回和枕中回之外，还报告了单侧的代谢低下，并且在致癫痫颞叶皮质的外侧和内侧结构中也有报告。随后的分析显示，颞叶低代谢仅存在于癫痫持续时间较长（≥10年）的患者中，海马旁回、钩回、颞中回和上级回（P < 0.05）。癫痫持续时间与致痫颞叶皮层颞下回、海马及海马旁回葡萄糖摄取减少呈负相关（P < 0.05）。除颞下回外，癫痫发作时的年龄对癫痫持续时间与葡萄糖摄取的相关性无影响（P> 0.05）。基于体素的映射支持这样的论断，即癫痫颞叶皮质和其他邻近皮质区域的葡萄糖代谢低下随着TLE中癫痫持续时间的延长而增加。
[18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) is a valuable method for detecting focal brain dysfunction associated with epilepsy. Evidence suggests that a progressive decrease in [18F]FDG uptake occurs in the epileptogenic cortex with an increase in the duration of epilepsy. In this study, our aim was to use statistical parametric mapping (SPM) to test the validity of this relationship in a retrospective study of patients with temporal lobe epilepsy (TLE). [18F]FDG-PET scans of 46 adult patients with pharmacoresistant unilateral TLE (25 RTLE and 21 LTLE) were subjected to SPM analysis. Forty-six patients were diagnosed with nonlesional TLE, 16 of whom had hippocampal sclerosis (HS). The average duration of epilepsy was 17.4 ± 12.3 years (3−46 years), <5 years in 10 patients and ≥10 years in 30 patients. Visual analysis of [18F]FDG-PET scans revealed hypometabolism in the epileptogenic temporal cortex in 31 (67%) patients. After SPM analysis of all [18F]FDG-PET images, hypometabolism was unilateral and reported in lateral and mesial structures of the epileptogenic temporal cortex in addition to the ipsilateral fusiform and middle occipital gyrus. Subsequent analysis revealed that temporal lobe hypometabolism was present only in patients with longer epilepsy duration (≥10 years) in parahippocampal gyrus, uncus, and middle and superior temporal gyrus (P < 0.05 corrected). Epilepsy duration was inversely correlated with decreased glucose uptake in the inferior temporal gyrus, hippocampus, and parahippocampal gyrus of the epileptogenic temporal cortex (P < 0.05). Age at seizure onset did not affect the correlation between epilepsy duration and glucose uptake except in the inferior temporal gyrus (P < 0.05). Voxel-based mapping supports the assertion that glucose hypometabolism of the epileptogenic temporal lobe cortex and other neighboring cortical regions increases with longer epilepsy duration in TLE.
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影响因子：
9.9
作者：
HENRY, TR;FREY, KA;KUHL, DE
通讯作者：
KUHL, DE
影响因子：
9.9
作者：
HAJEK, M;ANTONINI, A;WIESER, HG
通讯作者：
WIESER, HG
影响因子：
9.9
作者：
Riederer, F.;Lanzenberger, R.;Baumgartner, C.
通讯作者：
Baumgartner, C.
影响因子：
1.9
作者：
Benedek, Krisztina;Juhasz, Csaba;Chugani, Harry T.
通讯作者：
Chugani, Harry T.
影响因子：
2.2
作者：
Morgan, Victoria L.;Gore, John C.;Abou-Khalil, Basset
通讯作者：
Abou-Khalil, Basset