Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.
Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.
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血清生物标志物的时间变化和胃癌性病变进展的风险：一项纵向研究。
DOI：
10.1002/ijc.29005
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发表时间：
2015-01-15
影响因子：
6.4
通讯作者：
Yuan, Yuan
中科院分区：
文献类型：
--
作者：
Tu, Huakang;Sun, Liping;Dong, Xiao;Gong, Yuehua;Xu, Qian;Jing, Jingjing;Long, Qi;Flanders, W. Dana;Bostick, Roberd M.;Yuan, Yuan
有效地管理癌前病变是减少胃癌（GC）负担的关键。我们评估了多种血清学标志物（胃蛋白酶原I [PGI]、PGII、PGI/II比值、胃泌素-17和抗幽门螺杆菌IgG）的时间变化与胃癌前病变进展风险的相关性。1997年至2011年，在中国辽宁庄河市胃病筛查项目中，对2，039名参与者（5，070人次访视）进行了重复食管胃镜检查和胃粘膜活检及血液样本采集。血清生物标志物测定采用ELISA法，胃活检采用标准化的组织学标准进行评价。使用相关二元结局的广义估计方程估计比值比（OR）和95%置信区间（CI）。与血清PGI、PGII和抗H. pylori IgG水平升高≥50%者与降低≥50%者的相对值分别为1.67（CI，1.22-2.28）、1.80（CI，1.40-2.33）和1.93（CI，1.48-2.52）。PGI/II比值降低≥50%的患者相对于升高50%的患者的OR为1.40（CI，1.08-1.81），PGII和抗H.相对于水平均下降50%的患者，pylori IgG水平均升高≥50%，OR为3.18（CI，2.05-4.93）。胃泌素-17的变化与进展无统计学显著相关性。这些结果表明，血清PGI，PGII，PGI/II比值和抗H。pylori IgG水平（尤其是PGII和抗H. pylori IgG结合）可能有助于评估和管理胃癌前病变进展的风险。
Effectively managing precancerous lesions is crucial to reducing the gastric cancer (GC) burden. We evaluated associations of temporal changes in multiple serological markers (pepsinogen I [PGI], PGII, PGI/II ratio, gastrin-17 and anti-Helicobacter pylori IgG) with risk for progression of gastric precancerous lesions. From 1997 to 2011, repeated esophagogastroduodenoscopies with gastric mucosal biopsies and blood sample collections were conducted on 2,039 participants (5,070 person-visits) in the Zhuanghe Gastric Diseases Screening Program, Liaoning, China. Serum biomarkers were measured using ELISA, and gastric biopsies were evaluated using standardized histologic criteria. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using generalized estimating equations for correlated binary outcomes. The ORs for progression of gastric conditions comparing those whose serum PGI, PGII, and anti-H. pylori IgG levels increased ≥50% relative to those whose decreased ≥50% were, respectively 1.67 (CI, 1.22-2.28), 1.80 (CI, 1.40-2.33) and 1.93 (CI, 1.48-2.52). The OR for those whose PGI/II ratio decreased ≥50% relative to those whose increased 50% was 1.40 (CI, 1.08-1.81), and for those whose PGII and anti-H. pylori IgG levels both increased ≥50% relative to those whose levels both decreased 50% the OR was 3.18 (CI, 2.05-4.93). Changes in gastrin-17 were not statistically significantly associated with progression. These findings suggest that temporal changes in serum PGI, PGII, PGI/II ratio, and anti-H. pylori IgG levels (especially PGII and anti-H. pylori IgG combined) may be useful for assessing and managing risk for progression of gastric precancerous lesions.
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影响因子：
10.3
作者：
Correa, P;Fontham, ETH;Mera, R
通讯作者：
Mera, R
DOI：
10.1111/j.1349-7006.1995.tb03317.x
发表时间：
1995-12-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
Hattori, Y;Tashiro, H;Kodama, Y
通讯作者：
Kodama, Y
影响因子：
6.4
作者：
Knekt, Paul;Teppo, Lyly;Kosunen, Timo U.
通讯作者：
Kosunen, Timo U.
DNA碱基切除修复基因多态性与中国人群胃癌前病变演变的关系
影响因子：
4.7
作者：
Li, Wen-Qing;Zhang, Lian;You, Wei-Cheng
通讯作者：
You, Wei-Cheng
影响因子：
24.5
作者：
Kuipers, EJ;Nelis, GF;Walan, A
通讯作者：
Walan, A