Structural MRI Study of the Planum Temporale in Individuals With an At-Risk Mental State Using Labeled Cortical Distance Mapping.
Structural MRI Study of the Planum Temporale in Individuals With an At-Risk Mental State Using Labeled Cortical Distance Mapping.
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DOI：
10.3389/fpsyt.2020.593952
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发表时间：
2020
影响因子：
4.7
通讯作者：
Suzuki M
中科院分区：
文献类型：
--
作者：
Takayanagi Y;Kulason S;Sasabayashi D;Takahashi T;Katagiri N;Sakuma A;Ohmuro N;Katsura M;Nishiyama S;Nakamura M;Kido M;Furuichi A;Noguchi K;Matsumoto K;Mizuno M;Ratnanather JT;Suzuki M
背景：最近的研究表明，在患有高危精神状态（ARMS）的个体中，大脑结构的变化早于或伴随着明显的精神病（例如精神分裂症）的发作。颞平面 (PT) 是参与语言处理的大脑区域。在精神分裂症患者中，灰质体积减少和 PT 缺乏正常不对称性（左 > 右）已被多次报道。一些研究表明，首发精神分裂症患者以及 ARMS 受试者在精神病发展过程中灰质的 PT 进行性减少。方法：从三个地点（富山大学、东邦大学和东北大学）的 73 名 ARMS 受试者和 74 名性别和年龄匹配的健康对照获得 MRI 扫描（1.5 T 场强）。患有 ARMS 的参与者接受了至少 2 年的临床监测，以确认他们随后是否发展为明显的精神病。使用 FreeSurfer 发起的标记皮质距离测绘 (FSLCDM) 来估计 PT 的皮质厚度、灰质体积和表面积。对健康对照、后来出现明显精神病的 ARMS 受试者 (ARMS-P) 和未出现明显精神病的受试者 (ARMS-NP) 之间的 PT 测量进行了比较。在每个统计模型中，年龄、性别、颅内容积和扫描部位被视为有害协变量。结果：73 名 ARMS 受试者中，18 名在随访期内出现明显的精神病（12 名精神分裂症和 6 名其他精神病）。 PT 测量没有显着的组间差异。此外，在所有诊断组中都发现 PT 体积和表面积显着不对称（左 > 右）。 PT 测量与 ARMS 受试者的神经认知表现无关。讨论：我们的结果表明，先前报道的精神分裂症患者的灰质减少和缺乏正常的 PT 解剖不对称性可能不会在精神病的前驱阶段出现；结合之前的纵向研究结果，这种 PT 结构变化可能发生在精神病发作之前或期间。
Background: Recent studies have demonstrated brain structural changes that predate or accompany the onset of frank psychosis, such as schizophrenia, among individuals with an at-risk mental state (ARMS). The planum temporale (PT) is a brain region involved in language processing. In schizophrenia patients, gray matter volume reduction and lack of normal asymmetry (left > right) of PT have repeatedly been reported. Some studies showed progressive gray matter reduction of PT in first-episode schizophrenia patients, and in ARMS subjects during their development of psychosis. Methods: MRI scans (1.5 T field strength) were obtained from 73 ARMS subjects and 74 gender- and age-matched healthy controls at three sites (University of Toyama, Toho University and Tohoku University). Participants with ARMS were clinically monitored for at least 2 years to confirm whether they subsequently developed frank psychosis. Cortical thickness, gray matter volume, and surface area of PT were estimated using FreeSurfer-initiated labeled cortical distance mapping (FSLCDM). PT measures were compared among healthy controls, ARMS subjects who later developed overt psychosis (ARMS-P), and those who did not (ARMS-NP). In each statistical model, age, sex, intracranial volume, and scanning sites were treated as nuisance covariates. Results: Of 73 ARMS subjects, 18 developed overt psychosis (12 schizophrenia and 6 other psychoses) within the follow-up period. There were no significant group differences of PT measures. In addition, significant asymmetries of PT volume and surface area (left > right) were found in all diagnostic groups. PT measures did not correlate with the neurocognitive performance of ARMS subjects. Discussion: Our results suggest that the previously-reported gray matter reduction and lack of normal anatomical asymmetry of PT in schizophrenia patients may not emerge during the prodromal stage of psychosis; taken together with previous longitudinal findings, such PT structural changes may occur just before or during the onset of psychosis.
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影响因子：
2
作者：
Mizuno, Masafumi;Suzuki, Michio;Kurachi, Masayoshi
通讯作者：
Kurachi, Masayoshi
影响因子：
5.3
作者：
Hauser, Marta;Zhang, Jian-Ping;Correll, Christoph U.
通讯作者：
Correll, Christoph U.
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
5.6
作者：
Oertel-Knoechell, Viola;Linden, David E. J.
通讯作者：
Linden, David E. J.
影响因子：
5.7
作者：
Ratnanather, JT;Barta, PE;Miller, MI
通讯作者：
Miller, MI