Age-related changes in human peripapillary scleral strain.
Age-related changes in human peripapillary scleral strain.
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DOI：
10.1007/s10237-013-0517-9
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发表时间：
2014-06
影响因子：
3.5
通讯作者：
Downs, J. Crawford
中科院分区：
文献类型：
--
作者：
Fazio, Massimo A.;Grytz, Rafael;Morris, Jeffrey S.;Bruno, Luigi;Gardiner, Stuart K.;Girkin, Christopher A.;Downs, J. Crawford
为了检验人类后巩膜中的机械应变随年龄而改变的假设，在死后48小时内对来自20至90岁的人类供体的20对正常眼睛进行膨胀测试。将完整的后巩膜壳从5至45 mmHg加压，同时使用激光散斑干涉法测量巩膜表面的全场三维位移。直接从位移场计算外巩膜表面的全应变张量。计算视乳头周围和视神经乳头（ONH）周围中周区域内8个圆周部分（45°宽）的平均最大主（拉伸）应变。为了估计巩膜应变的年龄相关变化，使用考虑供体内变异性和空间自相关性的功能混合效应模型拟合结果。视乳头周围巩膜中的机械拉伸应变显著高于远离ONH的巩膜中的应变。总的来说，视乳头周围巩膜的应变随年龄的增长而显著降低。在较年轻的年龄段，鼻部的视乳头周围巩膜拉伸应变显著高于颞部，但随着年龄的增长，应变模式发生逆转，颞部在老年人中表现出最高的拉伸应变。总体而言，视乳头周围巩膜结构刚度随年龄显著增加。视乳头周围巩膜应变的扇形模式随着年龄的增长而逆转，这可能使筛板的邻近区域易于受到生物力学损伤。扇形视乳头周围巩膜应变的模式和年龄相关的变化与以前正常人受试者研究中报告的椎间盘突出和神经视网膜边缘面积测量变化率密切匹配。
To test the hypothesis that mechanical strain in the posterior human sclera is altered with age, twenty pairs of normal eyes from human donors aged 20 to 90 years old were inflation tested within 48 hours post mortem. The intact posterior scleral shells were pressurized from 5 to 45 mmHg while the full-field three-dimensional displacements of the scleral surface were measured using laser speckle interferometry. The full strain tensor of the outer scleral surface was calculated directly from the displacement field. Mean maximum principal (tensile) strain was computed for eight circumferential sectors (45° wide) within the peripapillary and mid-peripheral regions surrounding the optic nerve head (ONH). To estimate the age-related changes in scleral strain, results were fit using a functional mixed effects model that accounts for intra-donor variability and spatial autocorrelation. Mechanical tensile strain in the peripapillary sclera is significantly higher than the strain in the sclera farther away from the ONH. Overall, strains in the peripapillary sclera decrease significantly with age. Sectorially, peripapillary scleral tensile strains in the nasal sectors are significantly higher than the temporal sectors at younger ages, but the sectorial strain pattern reverses with age, and the temporal sectors exhibited the highest tensile strains in the elderly. Overall, peripapillary scleral structural stiffness increases significantly with age. The sectorial pattern of peripapillary scleral strain reverses with age, which may predispose adjacent regions of the lamina cribrosa to biomechanical insult. The pattern and age-related changes in sectorial peripapillary scleral strain closely match those seen in disk hemorrhages and neuroretinal rim area measurement change rates reported in previous studies of normal human subjects.
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影响因子：
2.4
作者：
Bornert, M.;Bremand, F.;Wattrisse, B.
通讯作者：
Wattrisse, B.
影响因子：
3.4
作者：
Fazio, Massimo A.;Bruno, Luigi;Downs, J. Crawford
通讯作者：
Downs, J. Crawford
影响因子：
4.2
作者：
Drance, S;Anderson, DR;Schulzer, M
通讯作者：
Schulzer, M
影响因子：
4.1
作者：
ALBON, J;KARWATOWSKI, WSS;DUANCE, VC
通讯作者：
DUANCE, VC
影响因子：
3.8
作者：
Eilaghi, Armin;Flanagan, John G.;Ethier, C. Ross
通讯作者：
Ethier, C. Ross