A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy.
A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy.
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DOI：
10.1088/0031-9155/60/13/5037
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发表时间：
2015-07-07
影响因子：
3.5
通讯作者：
Faddegon B
中科院分区：
文献类型：
--
作者：
Ramos-Méndez J;Perl J;Schümann J;Shin J;Paganetti H;Faddegon B
这项工作的目的是开发一个框架，用于在 TOPAS（粒子模拟工具）中模拟器官效应，该工具是 Geant4 蒙特卡罗工具包的包装，有助于粒子治疗模拟。 TOPAS 的 DICOM 接口已扩展为允许轮廓输入，用于将体素分配给器官。实施了以下剂量反应模型：Lyman-Kutcher-Burman模型、临界元素模型、基于群体的临界体积模型、并行串行模型、基于S形的Niemierko正常组织并发症概率（NTCP）和肿瘤控制概率（TCP）模型以及基于泊松的TCP模型。该框架允许轻松操纵这些模型的参数以及其他模型的实现。作为验证的一部分，将水体模 X 射线照射的并行-串行和泊松模型的结果与来自 AAPM 任务组 166 的数据进行了比较。当使用任务组剂量体积直方图 (DVH) 时，发现结果对 DVH 中的点数敏感，差异高达 2.4%，其中一些可归因于所实施模型之间的差异。新结果以指定的点间距给出。当将蒙特卡罗计算与 TOPAS 结合使用时，尽管与已发布的 DVH 匹配相对较好，但并行串行模型（最大 DVH 差异为 2%）的差异高达 9%，泊松模型（最大 DVH 差异为 0.5%）的差异高达 0.5%。然而，临界元素、临界体积和基于 sigmoid 的模型分别存在 74.5%（矩形 1）、34.8%（PTV）和 52.1%（三角形）的差异。我们提出了一个新的基准来验证质子治疗中的器官效应模型。该基准由扩展布拉格峰 (SOBP) 平台、正常组织、肿瘤、半影和远端区域的定制结构组成。提供了 DVH、DVH 点间距和器官效应模型的结果。这些模型用于计算头颈患者的剂量反应，以证明新框架的功能并表明质子治疗中模型之间的变异程度。
The aim of this work was to develop a framework for modeling organ effects within TOPAS (TOol for PArticle Simulation), a wrapper of the Geant4 Monte Carlo toolkit that facilitates particle therapy simulation. The DICOM interface for TOPAS was extended to permit contour input, used to assign voxels to organs. The following dose response models were implemented: The Lyman-Kutcher-Burman model, the critical element model, the population based critical volume model, the parallel-serial model, a sigmoid-based model of Niemierko for Normal Tissue Complication Probability (NTCP) and Tumor Control Probability (TCP), and a Poisson-based model for TCP. The framework allows easy manipulation of the parameters of these models and the implementation of other models. As part of the verification, results for the parallel-serial and Poisson model for x-ray irradiation of a water phantom were compared to data from the AAPM Task Group 166. When using the task group dose-volume histograms (DVHs), results were found to be sensitive to the number of points in the DVH, with differences up to 2.4%, some of which are attributable to differences between the implemented models. New results are given with the point spacing specified. When using Monte Carlo calculations with TOPAS, despite the relatively good match to the published DVH’s, differences up to 9% were found for the parallel-serial model (for a maximum DVH difference of 2%) and up to 0.5% for the Poisson model (for a maximum DVH difference of 0.5%). However, differences of 74.5% (in Rectangle1), 34.8% (in PTV) and 52.1% (in Triangle) for the critical element, critical volume and the sigmoid-based models were found respectively. We propose a new benchmark for verification of organ effect models in proton therapy. The benchmark consists of customized structures in the spread out Bragg peak (SOBP) plateau, normal tissue, tumor, penumbra and in the distal region. The DVH’s, DVH point spacing, and results of the organ effect models are provided. The models were used to calculate dose response for a Head and Neck patient to demonstrate functionality of the new framework and indicate the degree of variability between the models in proton therapy.
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影响因子：
2.1
作者：
Pyakuryal A;Myint WK;Gopalakrishnan M;Jang S;Logemann JA;Mittal BB
通讯作者：
Mittal BB
DOI：
10.1016/0360-3016(94)00475-z
发表时间：
1995-07-15
影响因子：
7
作者：
OKUNIEFF, P;MORGAN, D;SUIT, HD
通讯作者：
SUIT, HD
影响因子：
3.8
作者：
Paganetti, H;Jiang, H;Kooy, HM
通讯作者：
Kooy, HM
影响因子：
3.5
作者：
Schuemann, J.;Paganetti, H.;Perl, J.
通讯作者：
Perl, J.
影响因子：
3.8
作者：
Sawkey, D.;Faddegon, B. A.
通讯作者：
Faddegon, B. A.