A computational tool for the efficient analysis of dose-volume histograms from radiation therapy treatment plans.

A computational tool for the efficient analysis of dose-volume histograms from radiation therapy treatment plans.
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DOI:
10.1120/jacmp.v11i1.3013
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发表时间:
2010-01-28
影响因子:
2.1
通讯作者:
Mittal BB
Mittal BB
中科院分区:
医学4区
文献类型:
--
作者:
Pyakuryal A;Myint WK;Gopalakrishnan M;Jang S;Logemann JA;Mittal BB

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放射治疗直方图分析(HART)程序的开发主要是为了提高放射治疗研究中大量患者数据的剂量-体积直方图(DVH)分析的效率和准确性。该程序是用MATLAB编写的,用于分析从美国医学物理学家协会/放射治疗肿瘤组(AAPM/RTOG)格式的治疗计划系统导出的患者计划。HART计算的DVH数据与人工从计划系统中提取的5例接受调强放疗(IMRT)技术治疗的头颈癌患者的数据进行验证。HART在大约10-15分钟内从每位患者的差分DVH (dDVH)曲线中计算出4000多个参数。手动提取这个数量的数据需要5到6个小时。hart提取的DVH结果的标准化均方根偏差(NRMSD)小于1%,或在0.5%的距离-一致性(DTA)内。该工具支持各种用户友好的选项和图形显示。其他功能包括器官DVH曲线的最优多项式建模、治疗计划指数(TPI)评估、计划特异性结果分析(POA)以及空间DVH (zDVH)和剂量表面直方图(DSH)分析。HART是免费提供给放射肿瘤学社区。PACS数值:87.53.‐j;87.53.Tf;87.53.Xd。
A Histogram Analysis in Radiation Therapy (HART) program was primarily developed to increase the efficiency and accuracy of dose–volume histogram (DVH) analysis of large quantities of patient data in radiation therapy research. The program was written in MATLAB to analyze patient plans exported from the treatment planning system in the American Association of Physicists in Medicine/Radiation Therapy Oncology Group (AAPM/RTOG) format. HART‐computed DVH data was validated against manually extracted data from the planning system for five head and neck cancer patients treated with the intensity‐modulated radiation therapy (IMRT) technique. HART calculated over 4000 parameters from the differential DVH (dDVH) curves for each patient in approximately 10–15 minutes. Manual extraction of this amount of data required 5 to 6 hours. The normalized root mean square deviation (NRMSD) for the HART–extracted DVH outcomes was less than 1%, or within 0.5% distance‐to‐agreement (DTA). This tool is supported with various user‐friendly options and graphical displays. Additional features include optimal polynomial modeling of DVH curves for organs, treatment plan indices (TPI) evaluation, plan‐specific outcome analysis (POA), and spatial DVH (zDVH) and dose surface histogram (DSH) analyses, respectively. HART is freely available to the radiation oncology community. PACS numbers: 87.53.‐j; 87.53.Tf; 87.53.Xd.
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