Intrinsic connections of the macaque monkey hippocampal formation: I. Dentate gyrus.
Intrinsic connections of the macaque monkey hippocampal formation: I. Dentate gyrus.
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DOI：
10.1002/cne.21825
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发表时间：
2008-12-01
影响因子：
2.5
通讯作者：
Amaral, David G.
中科院分区：
文献类型：
--
作者：
Kondo, Hideki;Lavenex, Pierre;Amaral, David G.
我们对猕猴束状体海马形成的内在连通性进行了详细的分析。在这里，我们报告了齿状回主要连接的地形组织的发现。在齿状回的不同背侧水平注射局部顺行示踪剂，研究苔藓纤维的三维组织、相关投影和局部投影。苔藓状纤维在CA3的横向范围内沿起源细胞水平移动。一旦苔藓纤维到达CA3的远端部分，它们就会改变路线，并向上移动3-5毫米。联合突起起源于多态层的细胞，终止于分子层的内三分之一。相关的投射，虽然在起源水平上是适度的，但在齿状回的背侧和尾侧范围内，注射部位的背侧和尾侧范围可达80%。尾侧定向投影通常比喙侧定向投影更广泛和密集。多态层中的细胞产生局部突起，终止于分子层的外三分之二。这些突起在起源细胞的水平上密度最大，但也会向东延伸几毫米。总的来说，猴子齿状回内在连接的地形组织与大鼠的基本相似。如此广泛的纵向连接有可能在齿状回的大部分背侧区域整合信息。
We have carried out a detailed analysis of the intrinsic connectivity of the Macaca fascicularis monkey hippocampal formation. Here we report findings on the topographical organization of the major connections of the dentate gyrus. Localized anterograde tracer injections were made at various rostrocaudal levels of the dentate gyrus and we investigated the three-dimensional organization of the mossy fibers, the associational projection, and the local projections. The mossy fibers travel throughout the transverse extent of CA3 at the level of the cells of origin. Once the mossy fibers reach the distal portion of CA3, they change course and travel for 3–5 mm rostrally. The associational projection, originating from cells in the polymorphic layer, terminates in the inner third of the molecular layer. The associational projection, while modest at the level of origin, travels both rostrally and caudally from the injection site for as much as 80 percent of the rostrocaudal extent of the dentate gyrus. The caudally directed projection is typically more extensive and denser than the rostrally directed projection. Cells in the polymorphic layer originate local projections that terminate in the outer two-thirds of the molecular layer. These projections are densest at the level of the cells of origin, but also extend several millimeters rostrocaudally. Overall, the topographical organization of the intrinsic connections of the monkey dentate gyrus is largely similar to that of the rat. Such extensive longitudinal connections have the potential for integrating information across much of the rostrocaudal extent of the dentate gyrus.
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