Multi-spectral oscillatory dynamics serving directed and divided attention.
Multi-spectral oscillatory dynamics serving directed and divided attention.
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DOI：
10.1016/j.neuroimage.2020.116927
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发表时间：
2020-08-15
期刊：
影响因子：
5.7
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
McCusker MC;Wiesman AI;Schantell MD;Eastman JA;Wilson TW
与注意力相关的外部刺激的神经表征的放大在视觉领域已经有了很好的记录，然而，关于这种定向注意力的振荡动力学的研究在人类中相对较少。具体来说，目前还不清楚哪些频谱特异性神经反应主要受注意力方向和分配的影响，以及注意力对这些振荡的影响是否在空间上是不同的。在这项研究中，我们使用脑磁图和视觉-体感古怪的任务，调查定向（实验1; N = 26）和划分（实验2; N = 34）视觉注意的全脑振荡动力学。传感器级数据被转换到时间-频率域，并使用频率分辨波束形成器对基线的显著响应进行成像。我们发现，多光谱皮层振荡更强的注意力持续在视觉空间，这些影响表现出不同的频率信息的空间分布。更具体地说，我们发现，当视觉注意力持续时，额叶θ波（4-8 Hz）、额叶和枕叶α波（8-14 Hz）、枕叶β波（16-22 Hz）和额叶γ波（74-84 Hz）的反应比视觉注意力远离视觉域时更强。同样，在分散注意力的条件下，我们观察到更强的额顶叶θ活动和颞顶叶α和β振荡时，视觉注意力持续对视觉刺激比视觉和体感域之间划分。研究注意力增益是如何在人脑中实现的，对于更好地理解这一过程在疾病中是如何退化的至关重要，并可能为未来的治疗提供有用的靶点。
Attention-related amplification of neural representations of external stimuli has been well documented in the visual domain, however, research concerning the oscillatory dynamics of such directed attention is relatively sparse in humans. Specifically, it is unknown which spectrally-specific neural responses are mainly impacted by the direction and division of attention, as well as whether the effects of attention on these oscillations are spatially disparate. In this study, we use magnetoencephalography and a visual-somatosensory oddball task to investigate the whole-brain oscillatory dynamics of directed (Experiment 1; N = 26) and divided (Experiment 2; N = 34) visual attention. Sensor-level data were transformed into the time-frequency domain and significant responses from baseline were imaged using a frequency-resolved beamformer. We found that multi-spectral cortical oscillations were stronger when attention was sustained in the visual space and that these effects exhibited informative spatial distributions that differed by frequency. More specifically, we found stronger frontal theta (4–8 Hz), frontal and occipital alpha (8–14 Hz), occipital beta (16–22 Hz), and frontal gamma (74–84 Hz) responses when visual attention was sustained than when it was directed away from the visual domain. Similarly, in the divided attention condition, we observed stronger fronto-parietal theta activity and temporo-parietal alpha and beta oscillations when visual attention was sustained toward the visual stimuli than divided between the visual and somatosensory domains. Investigating how attentional gain is implemented in the human brain is essential for better understanding how this process is degraded in disease, and may provide useful targets for future therapies.
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