Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China.
Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China.
复制标题
血清尿酸与心房颤动之间的关联：一项基于中国社区的横断面研究。
DOI：
10.1136/bmjopen-2017-019037
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发表时间：
2017-12-22
期刊：
影响因子：
2.9
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Chen Y;Xia Y;Han X;Yang Y;Yin X;Qiu J;Liu H;Zhou Y;Liu Y
在中国社区人群中研究性别对血尿酸（SUA）水平与房颤（AF）患病率之间关系的影响。数据来源于冀东油田职工及家属的年度健康体检。冀东社区位于中国北方的唐山市。共有9078名居民被邀请参加调查，并提供知情同意书。排除了没有ECG或SUA数据的个人，我们的研究中剩下8937名居民。使用尿酸酶-过氧化物酶法在基线时测量SUA。高尿酸血症定义为男性SUA水平>7.0 mg/dL，女性>5.7 mg/dL。根据ECG结果和/或转诊医生的任何AF病史诊断AF。用逻辑回归分析评估SUA水平与AF患病率之间的粗略和独立相关性。AF患病率为0.6%（53/8937）。与SUA水平正常的受试者相比，高尿酸血症受试者的AF患病率更高（1.1% vs 0.5%; P=0.02）。在所有参与者中调整各种心血管危险因素后，高尿酸血症与AF相关（P=0.03，OR 2.051，95%CI 1.063至3.856）。与男性相比，女性的这种相关性尤其强（女性P<0.001，OR 6.366，95% CI 2.553至15.871;男性P=0.96，OR 1.025，95% CI 0.400至2.626）。我们证明了中国人群中SUA水平升高与AF患病率之间的显著相关性。我们的数据表明，有一个性别特异性机制之间的关系SUA和AF。
To investigate the effects of gender on the association of serum uric acid (SUA) levels and atrial fibrillation (AF) prevalence in a community-based Chinese population. Data were obtained from annual Jidong Oilfield employee and family member health checkups. The Jidong community is geographically located in Tangshan City in northern China. A total of 9078 residents were invited to take part in the survey and provided informed consents. Individuals without data of ECG or SUA were excluded, leaving 8937 residents in our study. SUA was measured at baseline using the uricase-peroxidase method. Hyperuricaemia was defined as a SUA level >7.0 mg/dL in men and >5.7 mg/dL in women. AF was diagnosed based on ECG findings and/or any medical history of AF from referring physicians. The crude and independent association between SUA levels and AF prevalence was evaluated with logistic regression analysis. AF prevalence was 0.6% (53/8937). Participants with hyperuricaemia had a higher AF prevalence compared with those with normal SUA levels (1.1% vs 0.5%; P=0.02). Hyperuricaemia was correlated with AF after adjustment for various cardiovascular risk factors in all participants (P=0.03, OR 2.051, 95% CI 1.063 to 3.856). This correlation was particularly stronger in women compared with men (P<0.001, OR 6.366, 95% CI 2.553 to 15.871 in women and P=0.96, OR 1.025, 95% CI 0.400 to 2.626 in men). We demonstrated a significant association between increased SUA levels and AF prevalence in a Chinese population. Our data indicate that there is a gender-specific mechanism underlying the relationship between SUA and AF.
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影响因子：
1.6
作者：
Liu, Yuansheng;Liu, Hao;Gu, Jihong
通讯作者：
Gu, Jihong
影响因子：
4.6
作者：
Li Z;Yang X;Wang A;Qiu J;Wang W;Song Q;Wang X
通讯作者：
Wang X
影响因子：
6.1
作者：
Nyrnes, Audhild;Toft, Ingrid;Lochen, Maja-Lisa
通讯作者：
Lochen, Maja-Lisa
影响因子：
1.2
作者：
Liu, Tong;Zhang, Xiaowei;Li, Guangping
通讯作者：
Li, Guangping
影响因子：
37.8
作者：
Aviles, RJ;Martin, DO;Chung, MK
通讯作者：
Chung, MK