A cFos activation map of remote fear memory attenuation.
A cFos activation map of remote fear memory attenuation.
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DOI：
10.1007/s00213-018-5000-y
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发表时间：
2019-01
影响因子：
3.4
通讯作者：
Gräff J
中科院分区：
文献类型：
--
作者：
Silva BA;Burns AM;Gräff J
强烈创伤的经历导致形成持久的恐惧记忆，可能退化为创伤后应激障碍。对这种情况最成功的治疗方法之一是灭绝训练，在此期间，在安全的环境中反复暴露于创伤诱导刺激，导致创伤相关记忆中的恐惧成分减弱。虽然许多研究已经调查了最近的神经基质（例如，1天大）恐惧记忆衰减，更少有人知道神经网络介导的衰减远程（例如，30日龄）恐惧记忆。由于消退训练在创伤记忆最初编码后很长时间内应用时效果变差，这代表了记忆研究中的一个重要空白。在这里，我们的目标是在小鼠中有效的远程恐惧记忆衰减后生成一个全面的大脑激活图。我们开发了一种有效的灭绝训练范式，用于1个月大的情境恐惧记忆衰减，并对一组皮质、杏仁核、丘脑和海马区域进行了cFos免疫组织化学和网络连接分析。远程恐惧记忆衰减诱导cFos在前边缘皮层，基底外侧杏仁核，丘脑的核reuniens，和腹侧领域的海马CA1和CA3。所有这些结构都同样被遥远的恐惧记忆回忆所吸收，而不是被熟悉的中性背景所吸收。这些结果表明，渐进的恐惧衰减介导的重复曝光是伴随着持续的神经元激活，而不是恢复到预处理的大脑状态。这些发现有助于确定脑区作为创伤记忆治疗方法的靶点。
The experience of strong traumata leads to the formation of enduring fear memories that may degenerate into post-traumatic stress disorder. One of the most successful treatments for this condition consists of extinction training during which the repeated exposure to trauma-inducing stimuli in a safe environment results in an attenuation of the fearful component of trauma-related memories. While numerous studies have investigated the neural substrates of recent (e.g., 1-day-old) fear memory attenuation, much less is known about the neural networks mediating the attenuation of remote (e.g., 30-day-old) fear memories. Since extinction training becomes less effective when applied long after the original encoding of the traumatic memory, this represents an important gap in memory research. Here, we aimed to generate a comprehensive map of brain activation upon effective remote fear memory attenuation in the mouse. We developed an efficient extinction training paradigm for 1-month-old contextual fear memory attenuation and performed cFos immunohistochemistry and network connectivity analyses on a set of cortical, amygdalar, thalamic, and hippocampal regions. Remote fear memory attenuation induced cFos in the prelimbic cortex, the basolateral amygdala, the nucleus reuniens of the thalamus, and the ventral fields of the hippocampal CA1 and CA3. All these structures were equally recruited by remote fear memory recall, but not by the recall of a familiar neutral context. These results suggest that progressive fear attenuation mediated by repetitive exposure is accompanied by sustained neuronal activation and not reverted to a pre-conditioning brain state. These findings contribute to the identification of brain areas as targets for therapeutic approaches against traumatic memories.
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影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
通讯作者：
Hamilton PW
影响因子：
5.3
作者：
Bernier, Brian E.;Lacagnina, Anthony F.;Drew, Michael R.
通讯作者：
Drew, Michael R.
影响因子：
56.9
作者：
Frankland, PW;Bontempi, B;Silva, AJ
通讯作者：
Silva, AJ
DOI：
10.1523/jneurosci.2107-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Corcoran KA;Donnan MD;Tronson NC;Guzmán YF;Gao C;Jovasevic V;Guedea AL;Radulovic J
通讯作者：
Radulovic J
影响因子：
2.7
作者：
Corcoran KA;Frick BJ;Radulovic J;Kay LM
通讯作者：
Kay LM