Translational Applications of Hydrogels.
Translational Applications of Hydrogels.
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DOI：
10.1021/acs.chemrev.0c01177
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发表时间：
2021-09-22
期刊：
影响因子：
62.1
通讯作者：
Appel EA
中科院分区：
文献类型：
--
作者：
Correa S;Grosskopf AK;Lopez Hernandez H;Chan D;Yu AC;Stapleton LM;Appel EA
水凝胶技术的进步已经解锁了独特而有价值的能力，这些能力正在应用于各种转化应用。水凝胶执行与一系列生物医学材料相关的功能-它们可以递送药物或细胞，再生硬组织和软组织，粘附湿组织，防止出血，在成像期间提供对比，在放射治疗期间保护组织或器官，以及改善医疗植入物的生物相容性。这些能力使水凝胶可用于许多不同的和紧迫的疾病和医疗条件，甚至用于不太传统的领域，如环境工程。在这篇综述中，我们涵盖了水凝胶的主要功能，重点是可注射水凝胶的新优势，以及它们如何与医学和环境中的转化应用相关。我们密切关注当代水凝胶的发展如何需要广泛的跨学科合作，以完成从癌症免疫治疗到组织工程再到疫苗接种的高度特异性和复杂的生物学任务。我们补充了我们的讨论，临床前和临床开发的水凝胶与机械设计的考虑需要缩放注射水凝胶技术的临床应用。我们预计，读者将更全面地了解水凝胶在众多领域和生物医学应用中产生实际和有影响力的差异的广阔可能性。
Advances in hydrogel technology have unlocked unique and valuable capabilities that are being applied to a diverse set of translational applications. Hydrogels perform functions relevant to a range of biomedical purposes—they can deliver drugs or cells, regenerate hard and soft tissues, adhere to wet tissues, prevent bleeding, provide contrast during imaging, protect tissues or organs during radiotherapy, and improve the biocompatibility of medical implants. These capabilities make hydrogels useful for many distinct and pressing diseases and medical conditions and even for less conventional areas such as environmental engineering. In this review, we cover the major capabilities of hydrogels, with a focus on the novel benefits of injectable hydrogels, and how they relate to translational applications in medicine and the environment. We pay close attention to how the development of contemporary hydrogels requires extensive interdisciplinary collaboration to accomplish highly specific and complex biological tasks that range from cancer immunotherapy to tissue engineering to vaccination. We complement our discussion of preclinical and clinical development of hydrogels with mechanical design considerations needed for scaling injectable hydrogel technologies for clinical application. We anticipate that readers will gain a more complete picture of the expansive possibilities for hydrogels to make practical and impactful differences across numerous fields and biomedical applications.
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DOI：
10.1016/j.ejpb.2015.05.022
发表时间：
2015-09
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
--
作者：
Annabi N;Yue K;Tamayol A;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
7.5
作者：
Amer MH;Rose FRAJ;Shakesheff KM;White LJ
通讯作者：
White LJ
影响因子：
1.7
作者：
Lins RD;Gomes RC;Santos KS;Silva PV;Silva RT;Ramos IA
通讯作者：
Ramos IA
影响因子：
3.7
作者：
Ali, Omar A.;Doherty, Ed;Emerich, Dwaine F.
通讯作者：
Emerich, Dwaine F.
影响因子：
7.2
作者：
Amer MH;Rose FRAJ;Shakesheff KM;Modo M;White LJ
通讯作者：
White LJ